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Open AccessInhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity
The oxidative phosphorylation system1 in mammalian mitochondria plays a key role in transducing energy from ingested nutrients2. Mitochondrial metabolism is dynamic and can be reprogrammed to support both catabol...
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Exercise metabolism and adaptation in skeletal muscle
Viewing metabolism through the lens of exercise biology has proven an accessible and practical strategy to gain new insights into local and systemic metabolic regulation. Recent methodological developments hav...
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Open AccessUnderstanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary
Exercise is a cornerstone of preventive medicine and a promising strategy to intervene on the biology of aging. Variation in the response to exercise is a widely accepted concept that dates back to the 1980s w...
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Reply to ‘Lactate as a major myokine and exerkine’
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Open AccessGenome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a m...
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Exerkines in health, resilience and disease
The health benefits of exercise are well-recognized and are observed across multiple organ systems. These beneficial effects enhance overall resilience, healthspan and longevity. The molecular mechanisms that ...
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Open AccessImpaired phosphocreatine metabolism in white adipocytes promotes inflammation
The mechanisms promoting disturbed white adipocyte function in obesity remain largely unclear. Herein, we integrate white adipose tissue (WAT) metabolomic and transcriptomic data from clinical cohorts and find...
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Open AccessEndurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism
Skeletal muscle is a highly adaptable tissue and remodels in response to exercise training. Using short RNA sequencing, we determine the miRNA profile of skeletal muscle from healthy male volunteers before and...
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Open AccessBranched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes
Increased levels of branched-chain amino acids (BCAAs) are associated with type 2 diabetes pathogenesis. However, most metabolomic studies are limited to an analysis of plasma metabolites under fasting conditi...
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Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men
The proliferation in the rate of diagnosis of obesity and type 2 diabetes mellitus continues unabated, with current recommendations for primary lifestyle changes (i.e. modification to dietary patterns) having ...
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Open AccessAuthor Correction: Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessTime-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient composition or energy restriction. To elucidate mechanisms underpinning the effects of short-term TRF, we investigated ske...
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Open AccessTrain like an athlete: applying exercise interventions to manage type 2 diabetes
Exercise elicits high energy demands, stimulating cardiorespiratory function and substrate mobilisation and oxidation. Repeated bouts of exercise lead to whole-body adaptations, which improve athletic performa...
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Open AccessTranscriptomic profiling of skeletal muscle adaptations to exercise and inactivity
The molecular mechanisms underlying the response to exercise and inactivity are not fully understood. We propose an innovative approach to profile the skeletal muscle transcriptome to exercise and inactivity u...
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Open AccessMajor Advances and Discoveries in Diabetes - 2019 in Review
This review is based on a recent invited lecture at the American Diabetes Association’s 79th annual Scientific Sessions entitled “Major Advances and Discoveries in Diabetes - The Year in Review.”
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Circadian rhythms and exercise — re-setting the clock in metabolic disease
Perturbed diurnal rhythms are becoming increasingly evident as deleterious events in the pathology of metabolic diseases. Exercise is well characterized as a crucial intervention in the prevention and treatmen...
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Open AccessAfternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial
Exercise is recommended for the treatment and prevention of type 2 diabetes. However, the most effective time of day to achieve beneficial effects on health remains unknown. We aimed to determine whether exerc...
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Open AccessFAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle
Insulin-mediated signals and AMP-activated protein kinase (AMPK)-mediated signals are activated in response to physiological conditions that represent energy abundance and shortage, respectively. Focal adhesio...
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The role of diet and exercise in the transgenerational epigenetic landscape of T2DM
Epigenetic processes have been implicated in the pathogenesis of type 2 diabetes mellitus
Diet and exercise...
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Erratum to: Turning the page