35 Result(s)

Article

Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity

The oxidative phosphorylation system¹ in mammalian mitochondria plays a key role in transducing energy from ingested nutrients². Mitochondrial metabolism is dynamic and can be reprogrammed to support both catabol...

Shan Jiang, Taolin Yuan, Florian A. Rosenberger, Arnaud Mourier… in Nature Metabolism (2024)

Article

Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary

Exercise is a cornerstone of preventive medicine and a promising strategy to intervene on the biology of aging. Variation in the response to exercise is a widely accepted concept that dates back to the 1980s w...

Melissa L. Erickson, Jacob M. Allen, Daniel P. Beavers, Linda M. Collins… in GeroScience (2023)

Article

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a m...

Zhe Wang, Andrew Emmerich, Nicolas J. Pillon, Tim Moore, Daiane Hemerich… in Nature Genetics (2022)

Article

Exerkines in health, resilience and disease

The health benefits of exercise are well-recognized and are observed across multiple organ systems. These beneficial effects enhance overall resilience, healthspan and longevity. The molecular mechanisms that ...

Lisa S. Chow, Robert E. Gerszten, Joan M. Taylor… in Nature Reviews Endocrinology (2022)

Article

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation

The mechanisms promoting disturbed white adipocyte function in obesity remain largely unclear. Herein, we integrate white adipose tissue (WAT) metabolomic and transcriptomic data from clinical cohorts and find...

Salwan Maqdasy, Simon Lecoutre, Gianluca Renzi, Scott Frendo-Cumbo… in Nature Metabolism (2022)

Article

Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism

Skeletal muscle is a highly adaptable tissue and remodels in response to exercise training. Using short RNA sequencing, we determine the miRNA profile of skeletal muscle from healthy male volunteers before and...

Julie Massart, Rasmus J. O. Sjögren, Brendan Egan, Christian Garde… in Nature Communications (2021)

Article

Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes

Increased levels of branched-chain amino acids (BCAAs) are associated with type 2 diabetes pathogenesis. However, most metabolomic studies are limited to an analysis of plasma metabolites under fasting conditi...

Rasmus J. O. Sjögren, David Rizo-Roca, Alexander V. Chibalin, Elin Chorell… in Diabetologia (2021)

Article

Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men

The proliferation in the rate of diagnosis of obesity and type 2 diabetes mellitus continues unabated, with current recommendations for primary lifestyle changes (i.e. modification to dietary patterns) having ...

John A. Hawley, Paolo Sassone-Corsi, Juleen R. Zierath in Diabetologia (2020)

Article

Author Correction: Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Leonidas S. Lundell, Evelyn B. Parr, Brooke L. Devlin… in Nature Communications (2020)

Article

Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient composition or energy restriction. To elucidate mechanisms underpinning the effects of short-term TRF, we investigated ske...

Leonidas S. Lundell, Evelyn B. Parr, Brooke L. Devlin… in Nature Communications (2020)

Article

Train like an athlete: applying exercise interventions to manage type 2 diabetes

Exercise elicits high energy demands, stimulating cardiorespiratory function and substrate mobilisation and oxidation. Repeated bouts of exercise lead to whole-body adaptations, which improve athletic performa...

Mladen Savikj, Juleen R. Zierath in Diabetologia (2020)

Article

Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity

The molecular mechanisms underlying the response to exercise and inactivity are not fully understood. We propose an innovative approach to profile the skeletal muscle transcriptome to exercise and inactivity u...

Nicolas J. Pillon, Brendan M. Gabriel, Lucile Dollet… in Nature Communications (2020)

Article

Major Advances and Discoveries in Diabetes - 2019 in Review

This review is based on a recent invited lecture at the American Diabetes Association’s 79th annual Scientific Sessions entitled “Major Advances and Discoveries in Diabetes - The Year in Review.”

Juleen R. Zierath in Current Diabetes Reports (2019)

Article

Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial

Exercise is recommended for the treatment and prevention of type 2 diabetes. However, the most effective time of day to achieve beneficial effects on health remains unknown. We aimed to determine whether exerc...

Mladen Savikj, Brendan M. Gabriel, Petter S. Alm, Jonathon Smith… in Diabetologia (2019)

Article

FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle

Insulin-mediated signals and AMP-activated protein kinase (AMPK)-mediated signals are activated in response to physiological conditions that represent energy abundance and shortage, respectively. Focal adhesio...

David G. Lassiter, Carolina Nylén, Rasmus J. O. Sjögren… in Diabetologia (2018)

Article

Erratum to: Turning the page

Juleen R. Zierath in Diabetologia (2015)