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Article
Pharmacokinetics and Pharmacodynamics of Nonsteroidal Androgen Receptor Ligands
Testosterone and structurally related anabolic steroids have been used to treat hypogonadism, muscle wasting, osteoporosis, male contraception, cancer cachexia, anemia, and hormone replacement therapy in aging...
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Article
Discovery of cSNPs in pig using full-length enriched cDNA libraries of the Korean native pig as a source of genetic diversity
Clones from full-length enriched cDNA libraries serve as valuable resources for functional genomic studies. We analyzed 3.210 chromatograms obtained from sequencing the 5′-ends of brainstem, liver, neocortex, ...
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Article
Ion conducting properties of poly(ethylene oxide)-based electrolytes incorporating amorphous silica attached with imidazolium salts
Poly(ethylene oxide) (PEO)-based polymer electrolytes containing amorphous silica attached ionic liquid (IL) were studied in order to improve electrochemical and interfacial properties. An imidazolium salt suc...
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Article
Effect of pressure sensitive adhesive and vehicles on permeation of terbinafine across porcine hoof membrane
The purpose of this study was to investigate characteristics of transungual drug delivery and the feasibility of develo** a drug-in-adhesive formulation of terbinafine. The permeation of terbinafine from a P...
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Article
Effect of para halogen modification of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides on metabolism and clearance
The purpose of this study was to better understand why para-halogen modifications of S-3-(4-halophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl) propionamide selective androgen receptor modulator...
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Article
Open AccessTargeted Regression of Hepatocellular Carcinoma by Cancer-Specific RNA Replacement through MicroRNA Regulation
Hepatocellular carcinoma (HCC) has a high fatality rate and limited therapeutic options with side effects and low efficacy. Here, we proposed a new anti-HCC approach based on cancer-specific post-transcription...
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Article
Open AccessMemory programming in CD8+ T-cell differentiation is intrinsic and is not determined by CD4 help
CD8+ T cells activated without CD4+ T-cell help are impaired in memory expansion. To understand the underlying cellular mechanism, here we track the dynamics of helper-deficient CD8+ T-cell response to a minor hi...
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Protocol
Detection of Specific mRNA Molecules in Hydrocarbon-Degrading Bacteria
A number of methods for visualization of specific mRNAs in bacterial cells have been developed recently, but not all of them are suitable for environmental species when examined under harsh growth conditions (...
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Protocol
Deep Sequencing to Study Microbial Transcriptomic Responses to Hydrocarbon Degradation/Production/Stress
Until relatively recently, genome-wide bacterial transcription analysis has typically relied on oligonucleotide-based DNA microarrays. This approach, however, has drawbacks because of limitations of probe desi...
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Article
Open AccessCell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog
A hexanucleotide repeat expansion in the C9orf72 gene is the most common cause of inherited forms of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Both loss-of-function and gain-of-function m...
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Article
Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep
GABAergic Lhx6+ neurons in the ventral zona incerta promote both rapid eye movement and non-rapid eye movement sleep and inhibit the activity of wake-promoting GABAergic and Hcrt+ neurons of the lateral hypothala...
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Article
Correction: Corrigendum: Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep
Nature 548, 582–587 (2017); doi:10.1038/nature23663 In this Letter, the surname of author Vassilis Pachnis was misspelled as ‘Pachinis’. The original Letter has been corrected online.
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Article
Open AccessDynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes
Introduction of synthetic circuits into microbes creates competition between circuit and host genes for shared cellular resources, such as ribosomes. This can lead to the emergence of unwanted coupling between...
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Article
OpenMendel: a cooperative programming project for statistical genetics
Statistical methods for genome-wide association studies (GWAS) continue to improve. However, the increasing volume and variety of genetic and genomic data make computational speed and ease of data manipulation...
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Article
A quantitative method for proteome reallocation using minimal regulatory interventions
Engineering resource allocation in biological systems is an ongoing challenge. Organisms allocate resources for ensuring survival, reducing the productivity of synthetic biology functions. Here we present a ne...
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Article
Author Correction: A quantitative method for proteome reallocation using minimal regulatory interventions
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
HIGH CROSSOVER RATE1 encodes PROTEIN PHOSPHATASE X1 and restricts meiotic crossovers in Arabidopsis
Meiotic crossovers are tightly restricted in most eukaryotes, despite an excess of initiating DNA double-strand breaks. The majority of plant crossovers are dependent on class I interfering repair, with a mino...
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Article
Picking the right metaphors for addressing microbial systems: economic theory helps understanding biological complexity
Any descriptive language is necessarily metaphoric and interpretative. Two somewhat overlap**—but not identical—languages have been thoroughly employed in the last decade to address the issue of regulatory c...
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Article
Complete genome sequence of a putative novel cytorhabdovirus isolated from Rudbeckia sp.
Through high-throughput RNA sequencing, we discovered a putative new cytorhabdovirus in the seeds of Rudbeckia sp., which we have tentatively named “rudbeckia virus 1” (RudV1). Its complete 12,502-nt genomic sequ...
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Chapter and Conference Paper
A Local Assessment Approach for Diagnosis of Thermal Imaging-Based Palmar Hyperhidrosis
Hyperhidrosis is classified as a skin disease that causes excessive sweating due to emotional stress and lowers the quality of life according to the degree of discomfort. The most common palmar hyperhidrosis i...
