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Article
Pharmacokinetics and Pharmacodynamics of Nonsteroidal Androgen Receptor Ligands
Testosterone and structurally related anabolic steroids have been used to treat hypogonadism, muscle wasting, osteoporosis, male contraception, cancer cachexia, anemia, and hormone replacement therapy in aging...
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Article
OpenMendel: a cooperative programming project for statistical genetics
Statistical methods for genome-wide association studies (GWAS) continue to improve. However, the increasing volume and variety of genetic and genomic data make computational speed and ease of data manipulation...
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Article
Complete genome sequence of a putative novel cytorhabdovirus isolated from Rudbeckia sp.
Through high-throughput RNA sequencing, we discovered a putative new cytorhabdovirus in the seeds of Rudbeckia sp., which we have tentatively named “rudbeckia virus 1” (RudV1). Its complete 12,502-nt genomic sequ...
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Article
Complete genome and molecular characterization of a putative novel citrivirus from Rudbeckia sp.
We identified a tentative novel positive-strand RNA virus from Rudbeckia sp., namely, Rudbeckia citrivirus A (RuCVA). The complete genome sequence of the novel virus was 8821 nucleotides in length, excluding the ...
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Article
Open AccessA single-cell atlas of in vitro multiculture systems uncovers the in vivo lineage trajectory and cell state in the human lung
We present an in-depth single-cell atlas of in vitro multiculture systems on human primary airway epithelium derived from normal and diseased lungs of 27 individual donors. Our large-scale single-cell profilin...