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Article
Open AccessEvaluation of respiratory samples in etiology diagnosis and microbiome characterization by metagenomic sequencing
The application of clinical mNGS for diagnosing respiratory infections improves etiology diagnosis, however at the same time, it brings new challenges as an unbiased sequencing method informing all identified ...
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Article
Transcriptomic analysis of key genes and pathways in human bronchial epithelial cells BEAS-2B exposed to urban particulate matter
Urban particulate matter (PM), a great danger to public health, is associated with increasing risk of pulmonary diseases. However, the involved key genes and signaling pathways mediating the cellular responses...
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Article
Visuospatial memory uniquely predicts Chinese reading comprehension in Hong Kong typically develo** kindergarteners
This study investigated the direct and indirect roles of verbal and visuospatial memory in Chinese reading comprehension. One hundred twenty-eight Cantonese-speaking children participated in the study at the e...
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Article
Open AccessCircular RNAs: a rising star in respiratory diseases
Circular RNAs (CircRNAs), as a new class of non-coding RNA molecules that, unlike linear RNAs, have covalently closed loop structures from the ligation of exons, introns, or both. CircRNAs are widely expressed...
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Article
Tracking the Eye Movement of Four Years Old Children Learning Chinese Words
Storybook reading is the major source of literacy exposure for beginning readers. The present study tracked 4-year-old Chinese children’s eye movements while they were reading simulated storybook pages. Their ...
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Article
Open AccessUrban particulate matter (PM) suppresses airway antibacterial defence
Epidemiological studies have shown that urban particulate matter (PM) increases the risk of respiratory infection. However, the underlying mechanisms are poorly understood. PM has been postulated to suppress t...
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Article
Effect of memory CD4+ T cells’ signal transducer and activator of transcription (STATs) functional shift on cytokine-releasing properties in asthma
Recent data have demonstrated that long-lived memory T cells are present in the human lung and can play significant roles in the pathogenesis of specific allergic and autoimmune diseases. However, most evidenc...
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Article
Open AccessIL-27 attenuates airway inflammation in a mouse asthma model via the STAT1 and GADD45γ/p38 MAPK pathways
Asthma is prone to Th2-mediated chronic airway inflammation. Interleukin-27 (IL-27) is a member of the IL-12 family that promotes the differentiation of Th1 cells and inhibits Th2 cells. We use human/mouse CD4+ T...
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Article
Open AccessFibroblast Growth Factor-10 (FGF-10) Mobilizes Lung-resident Mesenchymal Stem Cells and Protects Against Acute Lung Injury
FGF-10 can prevent or reduce lung specific inflammation due to traumatic or infectious lung injury. However, the exact mechanisms are poorly characterized. Additionally, the effect of FGF-10 on lung-resident m...
