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Viable Mice with Extensive Gene Humanization (25-kbp) Created Using Embryonic Stem Cell/Blastocyst and CRISPR/Zygote Injection Approaches

Here, we describe an expansion of the typical DNA size limitations associated with CRISPR knock-in technology, more specifically, the physical extent to which mouse genomic DNA can be replaced with donor (in t...

Tiffany Leidy-Davis, Kai Cheng, Leslie O. Goodwin, Judith L. Morgan… in Scientific Reports (2018)