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Article
Open AccessAssociations between back pain across adulthood and spine shape in early old age in a British birth cohort
We aimed to examine whether back pain across adulthood was associated with spine shape at age 60–64 years. Data were from 1405 participants in the MRC National Survey of Health and Development, a nationally re...
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Article
Open AccessImaging biomarker roadmap for cancer studies
Imaging biomarkers (IBs) are used extensively in drug development and cancer research, but important differences exist between IBs and biospecimen-derived biomarkers. A tailored 'roadmap' is required for the d...
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Article
Open AccessInfluence of Polymorphisms in the RANKL/RANK/OPG Signaling Pathway on Volumetric Bone Mineral Density and Bone Geometry at the Forearm in Men
We sought to determine the influence of single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and OPG on volumetric bone mineral density (vBMD) and bone geometry at the radius in men. Pairwise tag SNPs (r ...
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Article
Open AccessA validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing Study
A number of single nucleotide polymorphisms (SNPs) have been associated with broadband ultrasound attenuation (BUA) and speed of sound (SOS) as measured by quantitative ultrasound (QUS) at the calcaneus in the...
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Article
Open AccessRadiation exposure in X-ray-based imaging techniques used in osteoporosis
Recent advances in medical X-ray imaging have enabled the development of new techniques capable of assessing not only bone quantity but also structure. This article provides (a) a brief review of the current X...
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Chapter and Conference Paper
Segmentation of Lumbar Vertebrae Using Part-Based Graphs and Active Appearance Models
The aim of the work is to provide a fully automatic method of segmenting vertebrae in spinal radiographs. This is of clinical relevance to the diagnosis of osteoporosis by vertebral fracture assessment, and to...
