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    Article

    A clinical calculator to predict disease outcomes in women with triple-negative breast cancer

    Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterized by substantial risks of early disease recurrence and mortality. We constructed and validated clinical calcula...

    Mei-Yin C. Polley, Roberto A. Leon-Ferre in Breast Cancer Research and Treatment (2021)

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    Article

    Verily project releases millions of factory-reared mosquitoes

    Judith A Gilbert, Lisa Melton in Nature Biotechnology (2018)

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    Article

    Impact of histopathology, tumor-infiltrating lymphocytes, and adjuvant chemotherapy on prognosis of triple-negative breast cancer

    Given its high recurrence risk, guidelines recommend systemic therapy for most patients with early-stage triple-negative breast cancer (TNBC). While some clinicopathologic factors and tumor-infiltrating lympho...

    Roberto A. Leon-Ferre, Mei-Yin Polley, Heshan Liu in Breast Cancer Research and Treatment (2018)

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    Article

    Mouse pharmacokinetics and metabolism of the curcumin analog, 4-piperidinone,3,5-bis[(2-fluorophenyl)methylene]-acetate(3E,5E) (EF-24; NSC 716993)

    Curcumin, a keto-enol constituent of turmeric, has in vitro and in vivo antitumor activity. However, in vivo potency is low due to poor oral absorption. The mono-carbonyl analog, 3,5-bis[(2-fluorophenyl)methyl...

    Joel M. Reid, Sarah A. Buhrow, Judith A. Gilbert in Cancer Chemotherapy and Pharmacology (2014)

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    Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice

    Cytidine drugs, such as gemcitabine, undergo rapid catabolism and inactivation by cytidine deaminase (CD). 3,4,5,6-tetrahydrouridine (THU), a potent CD inhibitor, has been applied preclinically and clinically ...

    Jan H. Beumer, Julie L. Eiseman, Judith A. Gilbert in Cancer Chemotherapy and Pharmacology (2011)

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    Article

    Function of delta opioid receptors in cultured cells

    The opiate receptor subtype with a high affinity for the endogenous opioids met5-enkephalin and leu5-enkephalin (δ receptor), has been demonstrated in murine neuroblastoma clones and their glioma hybrids to effec...

    Judith A. Gilbert, Elliott Richelson in Molecular and Cellular Biochemistry (1983)