Programmed Morphogenesis
Methods and Protocols
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Open AccessModelling post-implantation human development to yolk sac blood emergence
Implantation of the human embryo begins a critical developmental stage that comprises profound events including axis formation, gastrulation and the emergence of haematopoietic system1,2. Our mechanistic knowledg...
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Open AccessTraSig: inferring cell-cell interactions from pseudotime ordering of scRNA-Seq data
A major advantage of single cell RNA-sequencing (scRNA-Seq) data is the ability to reconstruct continuous ordering and trajectories for cells. Here we present TraSig, a computational method for improving the i...
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Neighborhood Impact Factor to Study Cell-Fate Decision-Making in Cellular Communities
Cell-fate determination is a function of cell-intrinsic and -extrinsic signaling cues. Understanding the design principles governing fate control in multicellular systems remains difficult to understand and an...
