3 Result(s)
within
Josh Lauring
Oncology
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Article
PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity
The combined contributions of oncogenes and tumor suppressor genes toward carcinogenesis remain poorly understood. Elucidation of cancer gene cooperativity can provide new insights leading to more effective us...
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Article
Open AccessEngineering targeted chromosomal amplifications in human breast epithelial cells
Chromosomal amplifications are among the most common genetic alterations found in human cancers. However, experimental systems to study the processes that lead to specific, recurrent amplification events in hu...
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Article
Open AccessThe growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation
Although a high frequency of androgen receptor (AR) expression in human breast cancers has been described, exploiting this knowledge for therapy has been challenging. This is in part because androgens can eith...
