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  1. Article

    Open Access

    Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease

    Cribriform prostate cancer, found in both invasive cribriform carcinoma (ICC) and intraductal carcinoma (IDC), is an aggressive histological subtype that is associated with progression to lethal disease. To de...

    Hong Yuen Wong, Quanhu Sheng, Amanda B. Hesterberg… in Nature Communications (2022)

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  2. No Access

    Article

    PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity

    The combined contributions of oncogenes and tumor suppressor genes toward carcinogenesis remain poorly understood. Elucidation of cancer gene cooperativity can provide new insights leading to more effective us...

    Sarah Croessmann, Hong Yuen Wong… in Breast Cancer Research and Treatment (2017)

  3. No Access

    Article

    The role of targeted therapy and biomarkers in breast cancer treatment

    Breast cancer is the most prevalent life-threatening cancer in women and the second leading cause of cancer associated deaths. Consequently, optimizing breast cancer therapy to increase cure rates in early sta...

    Alison T. Stopeck, Ursa Brown-Glaberman… in Clinical & Experimental Metastasis (2012)