Page
%P
![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity
The combined contributions of oncogenes and tumor suppressor genes toward carcinogenesis remain poorly understood. Elucidation of cancer gene cooperativity can provide new insights leading to more effective us...
-
Article
Open AccessEngineering targeted chromosomal amplifications in human breast epithelial cells
Chromosomal amplifications are among the most common genetic alterations found in human cancers. However, experimental systems to study the processes that lead to specific, recurrent amplification events in hu...