6 Result(s)
within
Joseph S. Janicki
Life Sciences
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Article
Tryptase activates isolated adult cardiac fibroblasts via protease activated receptor-2 (PAR-2)
Protease activated receptor-2 (PAR-2) derived cycloxygenase-2 (COX-2) was recently implicated in a cardiac mast cell and fibroblast cross-talk signaling cascade mediating myocardial remodeling secondary to mec...
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Article
Expression of matrix metalloproteinase activity in idiopathic dilated cardiomyopathy: A marker of cardiac dilatation
Background: Idiopathic dilated cardiomyopathy (DCM), ventricular systolic dysfunction and chamber dilatation are accompanied by architectural remodeling, wall thinning and cardiac myocyte slippage. Recent work h...
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Article
Gender mediated cardiac protection from adverse ventricular remodeling is abolished by ovariectomy
Gender differences in the prevalence of cardiovascular disease have been observed both clinically and experimentally. These cardioprotective effects have frequently been attributed to female hormones, however,...
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Chapter
Gender mediated cardiac protection from adverse ventricular remodeling is abolished by ovariectomy
Gender differences in the prevalence of cardiovascular disease have been observed both clinically and experimentally. These cardioprotective effects have frequently been attributed to female hormones, however,...
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Chapter
Ventricular Remodeling in Heart Failure: The Role of Myocardial Collagen
Collagen which is present in the myocardium in relatively small amounts is the most abundant structural protein of the connective tissue network. Its structural organization consists of a complex weave of coll...
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Chapter
Myocardial Collagen and Its Functional Role
Even though normally present in relatively small amounts, myocardial collagen strongly influences ventricular diastolic function. Removal of less than half of the normal amount results in a dilated ventricle w...
