Abstract
Even though normally present in relatively small amounts, myocardial collagen strongly influences ventricular diastolic function. Removal of less than half of the normal amount results in a dilated ventricle with increased compliance. In contrast, an abnormal increase in collagen concentration results in a stiffer myocardium and ventricular diastolic dysfunction.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Borg TK, Caulfield JB. The collagen matrix of the heart. Fed Proceedings 1981; 40: 2037–2041.
Janicki JS, Matsubara BB. Myocardial collagen and left ventricular diastolic function. In: Gaasch WH, LeWinter MM (eds), Left Ventricular Diastolic Dysfunction. Philadelphia: Lea&Febiger, 1993 (in press).
Matsubara BB, Henegar JR, Janicki JS. Role of normal fibrillar collagen matrix in determining size and function of rat left ventricle. Am J Physiol 1993; in press.
Robinson TF, Factor SM, Sonnenblick EH. The heart as a suction pump. Sci Am 1986; 254: 84–91.
Factor SM, Robinson TF, Dominitz R, Cho S. Alterations of the myocardial skeletal framework in acute myocardial infarction with and without ventricular rupture. Am J Cardiovas Pathol 1986; 1: 91–97.
Matsubara BB, Henegar JR, Janicki JS. Functional and morphological consequences of induced myocardial collagen damage. Circulation 1992; 86: 1–171.
Weber KT, Janicki JS, Shroff SG, Pick R, Chen RM, Bashey RI. Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium. Circ Res 1988; 62: 757–765.
Montfort I, Perez-Tamayo R. The distribution of collagenase in normal rat tissues. J Histochem Cytochem 1975; 23: 910–920.
O’Brien LJ, Moore CM. Connective tissue degradation and distensibility characteristics of the non-living heart. Experientia 1966; 22: 845–847.
Caulfield JB, Wolkowicz PE. Mechanisms for cardiac dilatation. Heart Failure J 1990; 6: 138–150.
Zhao M, Zhang H, Robinson TF, Factor SM, Sonnenblick EH, Eng C. Profound structural alterations of the extracellular collagen matrix in postischemic dysfunctional (“stunned”) but viable myocardium. J Am Coll Cardiol 1987; 10: 1322–1334.
Weber KT, Pick R, Janicki JS, Gadodia G, Lakier JB. Inadequate type I collagen fibers in dilated cardiopathy. Am Heart J 1988; 116: 1641–1646.
Abrahams C, Janicki JS, Weber KT. Myocardial hypertrophy in the macaque fascicularis: Structural remodeling of the collagen matrix. Lab Invest 1987; 56: 676–683.
Contard F, Koteliansky V, Marotte F, Dubus I, Rappaport L, Samuel J. Specific alterations in the distribution of extracellular matrix components within rat myocardium during the development of pressure overload. Lab Invest 1991; 64: 65–75.
Doering CW, Jalil JE, Janicki JS, Pick R, Aghili S, Abrahams C, Weber KT. Collagen network remodeling and diastolic stiffness of the rat left ventricle with pressure overload hypertrophy. Cardiovasc Res 1988; 22: 686–695.
Pearlman ES, Weber KT, Janicki JS, Pietra G, Fishman AP. Muscle fiber orientation and connective tissue content in the hypertrophied human heart. Lab Invest 1982; 46: 158–164.
Narayan S, Janicki JS, Shroff SG, Pick R, Weber KT. Myocardial collagen and mechanics after preventing hypertrophy in hypertensive rats. Am J Hypertens 1988; 2: 675–682.
Brilla CG, Janicki JS, Weber KT. Cardioreparative effects of lisinopril in rats with genetic hypertension and left ventricular hypertrophy. Circulation 1991; 83: 1771–1779.
Brilla CG, Pick R, Tan LB, Janicki JS, Weber KT. Remodeling of the rat right and left ventricles in experimental hypertension. Circ Res 1990; 67: 1355–1364.
Caulfield JB. Alterations in cardiac collagen with hypertrophy. Perspect Cardiovasc Res 1983; 8: 49–57.
Pick R, Janicki IS, Weber KT. Myocardial fibrosis in nonhuman primate with pressure overload hypertrophy. Am J Pathol 1989; 135: 771–781.
Bing OHL, Matsushita S, Fanburg BL, Levine HI. Mechanical properties of rat cardiac muscle during experimental hypertrophy. Circ Res 1971; 28: 234–245.
Holubarsch CH, Holubarsch T, Jacob R, Medugorac I, Thiedemann K. Passive elastic properties of myocardium in different models and stages of hypertrophy: A study comparing mechanical, chemical, and morphometric parameters. Perspect Cardiovasc Res 1983; 7: 323–336.
Jalil JE, Doering CW, Janicki JS, Pick R, Shroff S, Weber KT. Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle. Circ Res 1989; 64: 1041–1050.
Carroll EP, Janicki JS, Pick R, Weber KT. Myocardial stiffness and reparative fibrosis following coronary embolization in the rat. Cardiovasc Res 1989; 23: 655–661.
Bing OHL, Fanburg BL, Brooks WW, Matsushita S. The effect of the lathyrogen B—amino proprionitrile (BAPN) on the mechanical properties of experimentally hypertrophied rat cardiac muscle. Circ Res 1978; 43: 632–637.
Gelpi RJ, Pasipoularides A, Lader AS, Patrick TA, Chase N, Hittinger L, Shannon RP, Bishop SP, Vatner SF. Changes in diastolic cardiac function in develo** and stable perinephritic hypertension in conscious dogs. Circ Res 1991; 68: 555–567.
MacFarlane N, Northridge DB, Wright AR, Grant S, Dargie HJ. A comparative study of left ventricular structure and function in elite athletes. Brit J Sports Med 1991; 25: 45–48.
Nixon JV, Wright AR, Porter TR, Roy V, Arrowood JA. Effects of exercise on left ventricular diastolic performance in trained athletes. Am J Cardiol 1991; 68: 945–949.
Shapiro LM, McKenna WJ. Left ventricular hypertrophy: relation of structure to diastolic function in hypertension. Brit Heart J 1984; 51: 637–642.
Shahi M, Thom S, Poulter N, Sever PS, Foale RA. Regression of hypertensive left ventricular hypertrophy and left ventricular diastolic function. Lancet 1990; 336: 458–461.
Szlachcic J, Tubau JF, O’Kelly B, Massie BM. Correlates of diastolic filling abnormalities in hypertension: A Doppler echocardiographic study. Am Heart J 1990; 120: 386–391.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Janicki, J.S., Matsubara, B.B., Kabour, A. (1993). Myocardial Collagen and Its Functional Role. In: Sideman, S., Beyar, R. (eds) Interactive Phenomena in the Cardiac System. Advances in Experimental Medicine and Biology, vol 346. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2946-0_28
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2946-0_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6280-7
Online ISBN: 978-1-4615-2946-0
eBook Packages: Springer Book Archive