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  1. No Access

    Article

    Autophagy mediates degradation of nuclear lamina

    In response to cancer-associated stress, autophagy machinery mediates degradation of nuclear lamina components in mammals, suggesting that cells might degrade nuclear components to prevent tumorigenesis.

    Zhixun Dou, Caiyue Xu, Greg Donahue, Takeshi Shimi, Ji-An Pan, Jiajun Zhu… in Nature (2015)

  2. No Access

    Article

    NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity

    The Beclin 1-Vps34 complex, the core component of the class III phosphatidylinositol-3 kinase (PI3K-III), binds Atg14L or UVRAG to control different steps of autophagy. However, the mechanism underlying the co...

    Jiahong Lu, Liqiang He, Christian Behrends, Masatake Araki… in Nature Communications (2014)

  3. No Access

    Article

    Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4

    Mounting evidence indicates that oncogenic Ras can modulate cell autonomous inflammatory cytokine production, although the underlying mechanism remains unclear. Here we show that squamous cell carcinoma antige...

    Joseph M. Catanzaro, Namratha Sheshadri, Ji-An Pan, Yu Sun… in Nature Communications (2014)