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Article
Open AccessA pilot trial of intravital microscopy in the study of the tumor vasculature of patients with peritoneal carcinomatosis
Aberrancies in the tumor microvasculature limit the systemic delivery of anticancer agents, which impedes tumor response. Using human intravital microscopy (HIVM), we hypothesized that HIVM would be feasible i...
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Article
Open AccessDynamic control of tumor vasculature improves antitumor responses in a regional model of melanoma
Despite advances in therapy for melanoma, heterogeneous responses with limited durability represent a major gap in treatment outcomes. The purpose of this study was to determine whether alteration in tumor blo...
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Immunopathology of Bone and Connective Tissue Cancers and Immunotherapy of Sarcomas
Sarcomas have long been recognized as being immunoresponsive. Over one century ago, Coley’s toxin is regarded as one of the first forms of immunotherapy for the treatment of sarcoma. With advancements in molec...
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Article
Open AccessIntraoperative intravital microscopy permits the study of human tumour vessels
Tumour vessels have been studied extensively as they are critical sites for drug delivery, anti-angiogenic therapies and immunotherapy. As a preclinical tool, intravital microscopy (IVM) allows for in vivo real-t...
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Article
A murine model of targeted infusion for intracranial tumors
Historically, intra-arterial (IA) drug administration for malignant brain tumors including glioblastoma multiforme (GBM) was performed as an attempt to improve drug delivery. With the advent of percutaneous ne...
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Article
Quinacrine for extremity melanoma in a mouse model of isolated limb perfusion (ILP)
Quinacrine is a relatively non-toxic drug, once given almost exclusively for malaria. However, recent studies show that quinacrine can suppress nuclear factor-κB (NF-κB), and activate p53 signaling. We investi...
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Article
Inflammatory myofibroblastic tumor of the mesentery: a clinical dilemma
Although rare, extra-pulmonary inflammatory myofibroblastic tumors (IMTs) are becoming increasingly recognized. While surgical resection is currently an effective and accepted treatment for IMTs, the optimal m...
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Article
Primary immune surveillance: some like it hot
The thermal element of fever has been found to be beneficial in models of infectious disease. The contributions of fever-range temperatures to the efficacy of the adaptive immune response have only begun to be...
