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Article
Refinement of the canine CD1 locus topology and investigation of antibody binding to recombinant canine CD1 isoforms
CD1 molecules are antigen-presenting glycoproteins primarily found on dendritic cells (DCs) responsible for lipid antigen presentation to CD1-restricted T cells. Despite their pivotal role in immunity, little ...
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Article
Open AccessRNA-seq analyses of changes in the Anopheles gambiae transcriptome associated with resistance to pyrethroids in Kenya: identification of candidate-resistance genes and candidate-resistance SNPs
The extensive use of pyrethroids for control of malaria vectors, driven by their cost, efficacy and safety, has led to widespread resistance. To favor their sustainable use, the World Health Organization (WHO)...
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Article
Open AccessProbing functional polymorphisms in the dengue vector, Aedes aegypti
Dengue is the most prevalent arboviral disease world-wide and its primary vector is the mosquito Aedes aegypti. The current lack of commercially-available vaccines makes control of vector populations the only eff...
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Article
High density SNP map** and QTL analysis for fruit quality characteristics in peach (Prunus persica L.)
Single nucleotide polymorphisms (SNPs) were used to construct an integrated SNP linkage map of peach (Prunus persica (L.) Batsch). A set of 1,536 SNPs were evaluated with the GoldenGate® Genoty** assay in two m...
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Article
Open AccessReference genome-independent assessment of mutation density using restriction enzyme-phased sequencing
The availability of low cost sequencing has spurred its application to discovery and ty** of variation, including variation induced by mutagenesis. Mutation discovery is challenging as it requires a substant...
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Article
Open AccessWhole genome sequencing of peach (Prunus persica L.) for SNP identification and selection
The application of next generation sequencing technologies and bioinformatic scripts to identify high frequency SNPs distributed throughout the peach genome is described. Three peach genomes were sequenced usi...
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Article
Regulating filopodial dynamics through actin-depolymerizing factor/cofilin
The regulation of filopodial dynamics by neurotrophins and other guidance cues plays an integral role in growth cone pathfinding. Filopodia are F-actin-based structures that explore the local environment, gene...
