6 Result(s)
within
José I Martín-Subero
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessA lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions
LncRNAs have been shown to be direct players in chromatin regulation, but little is known about their role at active genomic loci. We investigate the role of lncRNAs in gene activation by profiling the RNA int...
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Article
Open AccessInsight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics
Genome-wide association studies have provided evidence for inherited genetic predisposition to chronic lymphocytic leukemia (CLL). To gain insight into the mechanisms underlying CLL risk we analyze chromatin a...
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Article
Open AccessLong non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response
lncRNAs make up a majority of the human transcriptome and have key regulatory functions. Here we perform unbiased de novo annotation of transcripts expressed during the human humoral immune response to find 30...
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Article
Open AccessDiscovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies
The indisputable role of epigenetics in cancer and the fact that epigenetic alterations can be reversed have favoured development of epigenetic drugs. In this study, we design and synthesize potent novel, sele...
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Article
Non-coding recurrent mutations in chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a comprehensive evaluation of t...
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Article
Non-coding recurrent mutations in chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a comprehensive evaluation of t...
