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  1. No Access

    Chapter

    Immunopathogenesis of Celiac Disease

    Celiac disease (CD) is a systemic disorder with an immunological basis caused by an abnormal immune response to cereal gluten proteins, affecting to genetically susceptible individuals. The interaction of gene...

    Eduardo Arranz, José A. Garrote in Advances in Celiac Disease (2022)

  2. Article

    Open Access

    Comprehensive genomic diagnosis of non-syndromic and syndromic hereditary hearing loss in Spanish patients

    Sensorineural hearing loss (SNHL) is the most common sensory impairment. Comprehensive next-generation sequencing (NGS) has become the standard for the etiological diagnosis of early-onset SNHL. However, accur...

    Rubén Cabanillas, Marta Diñeiro, Guadalupe A. Cifuentes… in BMC Medical Genomics (2018)

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  3. No Access

    Article

    TNF α and LT α gene polymorphisms as additional markers of celiac disease susceptibility in a DQ2-positive population

    TNFα and TNFβ, or linfotoxin (LTα), are two molecules playing an important role in inflammation. Their genes map on Chromosome 6, between the HLA class II and class I loci. Polymorphisms in, or near, TNF genes h...

    José A. Garrote, Eduardo Arranz, Juan J. Tellería, Jesús Castro… in Immunogenetics (2002)

  4. No Access

    Article

    The HLA-DRB4 gene is present in half of the Spanish HLA-DQ2-negative celiac patients

    We studied nine consecutive DQ2-negative celiacs [from a group of 186 consecutive celiac disease (CD) patients] for the presence of the HLA-DQB1, DRB1, and DRBx alleles. HLA-DR53 was present in only 5 out of 9 (...

    José A. Garrote, Eduardo Arranz, Alfredo Blanco-Quirós in Immunogenetics (2000)