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Open AccessCongratulations to Prof. em. Garth L. Nicolson – co-founder of Clinical & Experimental Metastasis
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Future Directions to Manage Wildlife Health in a Changing Climate
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Cancer microenvironment and genomics: evolution in process
Cancer heterogeneity is a result of genetic mutations within the cancer cells. Their proliferation is not only driven by autocrine functions but also under the influence of cancer microenvironment, which consi...
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Open AccessCorrection to: EGFR/Ras-induced CCL20 production modulates the tumour microenvironment
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Open AccessCorrection to: Assessment of incentivizing effects for cancer care frameworks
The article “Assessment of incentivizing effects for cancer care frameworks”, written by Jörg Haier, Jonathan Sleeman and Jürgen Schäfers, was originally published Online First without Open Access. After publi...
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Open AccessSociocultural incentives for cancer care implementation
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Open AccessEGFR/Ras-induced CCL20 production modulates the tumour microenvironment
The activation of the EGFR/Ras-signalling pathway in tumour cells induces a distinct chemokine repertoire, which in turn modulates the tumour microenvironment.
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Open AccessAssessment of incentivizing effects for cancer care frameworks
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Guidance of healthcare development for metastatic cancer patients as an example for setting incentives
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The contribution of platelets to intravascular arrest, extravasation, and outgrowth of disseminated tumor cells
Platelets are primarily known for their contribution to hemostasis and subsequent wound healing. In addition to these functions, platelets play a role in the process of metastasis. Since the first study that s...
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Editorial series: cancer care in low- and middle-income countries
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Open AccessCorrection to: Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours
In the publication of this article (1), there is an error in Fig. 5b. This has now been updated in the original article (1).
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Open AccessLiver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours
Although metabolism is profoundly altered in human liver cancer, the extent to which experimental models, e.g. cell lines, mimic those alterations is unresolved. Here, we aimed to determine the resemblance of ...
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Open AccessBASIS: High-performance bioinformatics platform for processing of large-scale mass spectrometry imaging data in chemically augmented histology
Mass Spectrometry Imaging (MSI) holds significant promise in augmenting digital histopathologic analysis by generating highly robust big data about the metabolic, lipidomic and proteomic molecular content of t...
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Open AccessIdentification of Two novel reassortant avian influenza a (H5N6) viruses in whooper swans in Korea, 2016
On November 20, 2016 two novel strains of H5N6 highly pathogenic avian influenza virus (HPAIVs) were isolated from three whooper swans (Cygnus cygnus) at Gang** Bay in South Jeolla province, South Korea. Identif...
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Open AccessHyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways
Intervertebral disc (IVD) degeneration is characterized by extracellular matrix breakdown and is considered to be a primary cause of discogenic back pain. Although increases in pro-inflammatory cytokine levels...
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Open AccessLiCl induces TNF-α and FasL production, thereby stimulating apoptosis in cancer cells
The incidence of cancer in patients with neurological diseases, who have been treated with LiCl, is below average. LiCl is a well-established inhibitor of Glycogen synthase kinase-3, a kinase that controls sev...
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Loss of CD24 expression promotes ductal branching in the murine mammary gland
CD24 is expressed on mammary stem cells and is used as a marker for their isolation, yet its function in the mammary gland still needs to be examined. Here we show that CD24 is expressed throughout the luminal...
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Lymphatic metastasis in breast cancer: importance and new insights into cellular and molecular mechanisms
Lymph node metastasis is the main prognosis factor in a number of malignancies, including breast carcinomas. The means by which lymph node metastases arise is not fully understood, and many questions remain ab...
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Cd44 and Splice Variants of Cd44 in Normal Differentiation and Tumor Progression
CD44, originally defined by antibodies as a leukocyte surface protein (reviewed in Haynes et al., 1989), has become a polymorphic family of proteins expressed in various cells and conditions. The polymorphism ...
