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  1. Article

    Open Access

    Plasmids in the human gut reveal neutral dispersal and recombination that is overpowered by inflammatory diseases

    Plasmids are pivotal in driving bacterial evolution through horizontal gene transfer. Here, we investigated 3467 human gut microbiome samples across continents and disease states, analyzing 11,086 plasmids. Ou...

    Alvah Zorea, David Pellow, Liron Levin, Shai Pilosof in Nature Communications (2024)

  2. Article

    Open Access

    Resolving the conflict between antibiotic production and rapid growth by recognition of peptidoglycan of susceptible competitors

    Microbial communities employ a variety of complex strategies to compete successfully against competitors sharing their niche, with antibiotic production being a common strategy of aggression. Here, by systemat...

    Harsh Maan, Maxim Itkin, Sergey Malitsky, Jonathan Friedman in Nature Communications (2022)

  3. Article

    Open Access

    Community composition of microbial microcosms follows simple assembly rules at evolutionary timescales

    Managing and engineering microbial communities relies on the ability to predict their composition. While progress has been made on predicting compositions on short, ecological timescales, there is still little...

    Nittay Meroz, Nesli Tovi, Yael Sorokin, Jonathan Friedman in Nature Communications (2021)

  4. Article

    Open Access

    Deciphering functional redundancy in the human microbiome

    Although the taxonomic composition of the human microbiome varies tremendously across individuals, its gene composition or functional capacity is highly conserved — implying an ecological property known as fun...

    Liang Tian, Xu-Wen Wang, Ang-Kun Wu, Yuhang Fan, Jonathan Friedman in Nature Communications (2020)

  5. Article

    Open Access

    Mortality causes universal changes in microbial community composition

    All organisms are sensitive to the abiotic environment, and a deteriorating environment can cause extinction. However, survival in a multispecies community depends upon interactions, and some species may even ...

    Clare I. Abreu, Jonathan Friedman, Vilhelm L. Andersen Woltz in Nature Communications (2019)

  6. Article

    Open Access

    Map** the ecological networks of microbial communities

    Map** the ecological networks of microbial communities is a necessary step toward understanding their assembly rules and predicting their temporal behavior. However, existing methods require assuming a parti...

    Yandong **ao, Marco Tulio Angulo, Jonathan Friedman in Nature Communications (2017)

  7. No Access

    Article

    Universality of human microbial dynamics

    A new computational method to characterize the dynamics of human-associated microbial communities is applied to data from two large-scale metagenomic studies, and suggests that gut and mouth microbiomes of hea...

    Amir Bashan, Travis E. Gibson, Jonathan Friedman, Vincent J. Carey in Nature (2016)

  8. No Access

    Article

    Ecology drives a global network of gene exchange connecting the human microbiome

    Horizontal gene transfer — the exchange of genetic material between different species or lineages — is an important factor in bacterial evolution. A study of human microbiome data comprising more than 2,000 fu...

    Chris S. Smillie, Mark B. Smith, Jonathan Friedman, Otto X. Cordero in Nature (2011)