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Article
The Role of Deimination in Regenerative Reprogramming of Neurons
Neurons from the adult central nervous system (CNS) demonstrate limited mRNA transport and localized protein synthesis versus develo** neurons, correlating with lower regenerative capacity. We found that dei...
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Chapter
Neurovascular Mechanisms of Ischemia Tolerance Against Brain Injury
Traumatic brain injury (TBI) can result in secondary ischemia. This secondary ischemic insult is implicated in post-TBI pathophysiology. Pharmacological intervention to elevate cerebral blood flow can improve ...
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Article
Ischemic Preconditioning Alters the Epigenetic Profile of the Brain from Ischemic Intolerance to Ischemic Tolerance
Ischemic preconditioning is an innate neuroprotective mechanism in which a sub-injurious ischemic exposure increases the brain’s ability to withstand a subsequent, normally injurious ischemic insult. Part of i...
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Chapter
Anoxia Resistance in Lower and Higher Vertebrates
The mammalian brain has a high obligatory rate of energy consumption which renders it extremely sensitive to even brief periods of oxygen deprivation. In contrast, the crucian carp (Carassius carassius) and some ...