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Article
The Role of Deimination in Regenerative Reprogramming of Neurons
Neurons from the adult central nervous system (CNS) demonstrate limited mRNA transport and localized protein synthesis versus develo** neurons, correlating with lower regenerative capacity. We found that dei...
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Article
Signaling pathways leading to ischemic mitochondrial neuroprotection
There is extensive evidence that ischemic/reperfusion mediated mitochondrial dysfunction is a major contributor to ischemic damage. However data also indicates that mild ischemic stress induces mitochondrial d...
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Chapter
Neurovascular Mechanisms of Ischemia Tolerance Against Brain Injury
Traumatic brain injury (TBI) can result in secondary ischemia. This secondary ischemic insult is implicated in post-TBI pathophysiology. Pharmacological intervention to elevate cerebral blood flow can improve ...
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Article
Ischemic Preconditioning Alters the Epigenetic Profile of the Brain from Ischemic Intolerance to Ischemic Tolerance
Ischemic preconditioning is an innate neuroprotective mechanism in which a sub-injurious ischemic exposure increases the brain’s ability to withstand a subsequent, normally injurious ischemic insult. Part of i...
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Chapter
Anoxia Resistance in Lower and Higher Vertebrates
The mammalian brain has a high obligatory rate of energy consumption which renders it extremely sensitive to even brief periods of oxygen deprivation. In contrast, the crucian carp (Carassius carassius) and some ...
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Chapter and Conference Paper
Differential Effects of Delta and Epsilon Protein Kinase C in Modulation of Postischemic Cerebral Blood Flow
Cerebral ischemia causes cerebral blood flow (CBF) derangements resulting in neuronal damage by enhanced protein kinase C delta (δPKC) levels leading to hippocampal and cortical neuronal death after ischemia. ...
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Article
Regulation of extracellular glutamate levels in the long-term anoxic turtle striatum: coordinated activity of glutamate transporters, adenosine, K ATP + channels and GABA
Early in anoxia the mammalian brain experiences an uncontrolled release of glutamate, which combined with the failure of glutamate reuptake mechanisms, leads to massive neurotoxic increases in extracellular gl...
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Article
Microprocessor-based multichannel analyzer system for NaI (Tl) detectors
A microcomputer-based multichannel analyzer system for NaI(Tl) scintillation detectors has been developed. This system simultaneously collects spectral data from two NaI(Tl) detectors, integrates spectral regi...
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Article
Educational psychologists and animal experiments
Stephen Wiseman has drawn attention to the gap between learning experiments with school children and experiments with rats and pigeons. However, educational psychologists such as Burt and Wiseman give little i...
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Article
Physiological Patterns and Mental Disturbances
THAT a diminution in the oxygen tension of the inspired air can produce mental changes is an established fact. Far less certain is the possible correlation between psychotic manifestations as seen in clinical ...