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  1. No Access

    Article

    The Role of Deimination in Regenerative Reprogramming of Neurons

    Neurons from the adult central nervous system (CNS) demonstrate limited mRNA transport and localized protein synthesis versus develo** neurons, correlating with lower regenerative capacity. We found that dei...

    Di Ding, Mabel Enriquez-Algeciras, Anddre Osmar Valdivia… in Molecular Neurobiology (2019)

  2. No Access

    Chapter

    Neurovascular Mechanisms of Ischemia Tolerance Against Brain Injury

    Traumatic brain injury (TBI) can result in secondary ischemia. This secondary ischemic insult is implicated in post-TBI pathophysiology. Pharmacological intervention to elevate cerebral blood flow can improve ...

    Kunjan R. Dave, John W. Thompson, Jake T. Neumann… in Vascular Mechanisms in CNS Trauma (2014)

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    Article

    Ischemic Preconditioning Alters the Epigenetic Profile of the Brain from Ischemic Intolerance to Ischemic Tolerance

    Ischemic preconditioning is an innate neuroprotective mechanism in which a sub-injurious ischemic exposure increases the brain’s ability to withstand a subsequent, normally injurious ischemic insult. Part of i...

    John W. Thompson, Kunjan R. Dave, Juan I. Young… in Neurotherapeutics (2013)

  4. No Access

    Chapter

    Anoxia Resistance in Lower and Higher Vertebrates

    The mammalian brain has a high obligatory rate of energy consumption which renders it extremely sensitive to even brief periods of oxygen deprivation. In contrast, the crucian carp (Carassius carassius) and some ...

    John W. Thompson, Göran E. Nilsson, Miguel A. Perez-Pinzon in Innate Tolerance in the CNS (2013)

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    Chapter and Conference Paper

    Differential Effects of Delta and Epsilon Protein Kinase C in Modulation of Postischemic Cerebral Blood Flow

    Cerebral ischemia causes cerebral blood flow (CBF) derangements resulting in neuronal damage by enhanced protein kinase C delta (δPKC) levels leading to hippocampal and cortical neuronal death after ischemia. ...

    Hung Wen Lin, David Della-Morte, John W. Thompson… in Oxygen Transport to Tissue XXXIII (2012)

  6. No Access

    Article

    Regulation of extracellular glutamate levels in the long-term anoxic turtle striatum: coordinated activity of glutamate transporters, adenosine, K ATP + channels and GABA

    Early in anoxia the mammalian brain experiences an uncontrolled release of glutamate, which combined with the failure of glutamate reuptake mechanisms, leads to massive neurotoxic increases in extracellular gl...

    John W. Thompson, Howard M. Prentice, Peter L. Lutz in Journal of Biomedical Science (2007)