20 Result(s)

Article

Models of Replicator Proliferation Involving Differential Replicator Subunit Stability

Several models for the origin of life involve molecules that are capable of self-replication, such as self-replicating polymers composed of RNA or DNA or amino acids. Here we consider a hypothetical replicator...

Zewei Li, Runhe Lyu, John Tower in Origins of Life and Evolution of Biospheres (2018)

Article

Erratum to: Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes

Christina Curtis, Gary N Landis, Donna Folk, Nancy B Wehr, Nicholas Hoe… in Genome Biology (2016)

Article

The wright stuff: reimagining path analysis reveals novel components of the sex determination hierarchy in drosophila melanogaster

The Drosophila sex determination hierarchy is a classic example of a transcriptional regulatory hierarchy, with sex-specific isoforms regulating morphology and behavior. We use a structural equation modeling appr...

Justin M. Fear, Michelle N. Arbeitman, Matthew P. Salomon… in BMC Systems Biology (2015)

Article

Natural variation of gene models in Drosophila melanogaster

Variation within splicing regulatory sequences often leads to differences in gene models among individuals within a species. Two alleles of the same gene may express transcripts with different exon/intron stru...

Yerbol Z Kurmangaliyev, Alexander V Favorov, Noha M Osman… in BMC Genomics (2015)

Article

Identifying sexual differentiation genes that affect Drosophila life span

Sexual differentiation often has significant effects on life span and aging phenotypes. For example, males and females of several species have different life spans, and genetic and environmental manipulations ...

Jie Shen, Daniel Ford, Gary N Landis, John Tower in BMC Geriatrics (2009)

Article

The genetics of gender and life span

Several possible and potentially overlap** genetic mechanisms have been suggested to explain differences in life span between males and females. Two recent papers in BMC Evolutionary Biology on the effects of i...

John Tower, Michelle Arbeitman in Journal of Biology (2009)

Article

Simultaneous tracking of movement and gene expression in multiple Drosophila melanogaster flies using GFP and DsRED fluorescent reporter transgenes

Fluorescent proteins such as GFP (Green Fluorescent Protein) and DsRED (Discosoma sp.Red Fluorescent Protein) are often used as reporter molecules for transgene expression in Drosophila and other species. We h...

Dhruv Grover, Junsheng Yang, Daniel Ford, Simon Tavaré, John Tower in BMC Research Notes (2009)

Article

Adult-specific over-expression of the Drosophila genes magu and hebe increases life span and modulates late-age female fecundity

During Drosophila aging mortality rate increases exponentially and progeny production per animal declines dramatically, correlating with decreased number and division of somatic and germ-line stem cells in the go...

Yishi Li, John Tower in Molecular Genetics and Genomics (2009)

Article

Simultaneous tracking of fly movement and gene expression using GFP

Green Fluorescent Protein (GFP) is used extensively as a reporter for transgene expression in Drosophila and other organisms. However, GFP has not generally been used as a reporter for circadian patterns of ge...

Dhruv Grover, Junsheng Yang, Simon Tavaré, John Tower in BMC Biotechnology (2008)

Article

Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophilareveals a species-general network of aging and metabolic genes

Several interventions increase lifespan in model organisms, including reduced insulin/insulin-like growth factor-like signaling (IIS), FOXO transcription factor activation, dietary restriction, and superoxide ...

Christina Curtis, Gary N Landis, Donna Folk, Nancy B Wehr, Nicholas Hoe… in Genome Biology (2007)

Article

A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctlgenes

A P-type transposable element called PdL has been engineered with a doxycycline-inducible promoter directed out through the 3' end of the element. Insertion of PdL near the 5' end of a gene often yields doxycycli...

Gary N Landis, Deepak Bhole, John Tower in Genome Biology (2003)

Article

Doxycycline-induced expression of sense and inverted-repeat constructs modulates phosphogluconate mutase (Pgm) gene expression in adult Drosophila melanogaster

A tetracycline-regulated (conditional) system for RNA interference (RNAi) would have many practical applications. Such a strategy was developed using RNAi of the gene for phosphogluconate mutase (Pgm). Pgm is a c...

Michael J Allikian, Denise Deckert-Cruz, Michael R Rose, Gary N Landis… in Genome Biology (2002)