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Open AccessCorrection: Correlative CD4 and CD8 T-cell immunodominance in humans and mice: implications for preclinical testing
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Open AccessCorrelative CD4 and CD8 T-cell immunodominance in humans and mice: Implications for preclinical testing
Antigen-specific T-cell recognition is restricted by Major Histocompatibility Complex (MHC) molecules, and differences between CD4 and CD8 immunogenicity in humans and animal species used in preclinical vaccin...
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Open AccessCD8+ T cells specific for cryptic apoptosis-associated epitopes exacerbate experimental autoimmune encephalomyelitis
The autoimmune immunopathology occurring in multiple sclerosis (MS) is sustained by myelin-specific and -nonspecific CD8+ T cells. We have previously shown that, in MS, activated T cells undergoing apoptosis indu...
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Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer
T cells are important in tumour immunity but a better understanding is needed of the differentiation of antigen-specific T cells in human cancer1,2. Here we studied CD8 T cells in patients with human papillomavir...
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Open AccessQuantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses
The magnitude of T cell responses to infection is a function of the naïve T cell repertoire combined with the context and duration of antigen presentation. Using mass spectrometry, we identify and quantify 21 ...
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Open AccessLow HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications
Type 1 diabetes (T1D) is thought to be an autoimmune disease driven by anti-islet antigen responses and mediated by T-cells. Recent published data suggests that T-cell reactivity to modified peptides, effectiv...
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Open AccessNovel Plasmodium antigens identified via genome-based antibody screen induce protection associated with polyfunctional T cell responses
The development of vaccines against complex intracellular pathogens, such as Plasmodium spp., where protection is likely mediated by cellular immune responses, has proven elusive. The availability of whole genome...
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Open AccessProtein nanovaccine confers robust immunity against Toxoplasma
We designed and produced a self-assembling protein nanoparticle. This self-assembling protein nanoparticle contains five CD8+ HLA-A03-11 supertypes-restricted epitopes from antigens expressed during Toxoplasma go...
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Erratum: T cells from patients with Parkinson’s disease recognize α-synuclein peptides
Nature 546, 656–661 (2017); doi:10.1038/nature22815 In this Letter, owing to an error during the production process, two values in Table 1 were incorrect. The relative frequency for the DQB1*03:04 allele shoul...
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Open AccessExperimental validation of the RATE tool for inferring HLA restrictions of T cell epitopes
The RATE tool was recently developed to computationally infer the HLA restriction of given epitopes from immune response data of HLA typed subjects without additional cumbersome experimentation.
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T cells from patients with Parkinson’s disease recognize α-synuclein peptides
Epitopes derived from two regions of α-synuclein elicit immune responses in patients with Parkinson’s disease, involving IL-5-secreting CD4+ T cells, as well as IFNγ-secreting CD8+ cytotoxic T cells.
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Peptide-binding motifs of two common equine class I MHC molecules in Thoroughbred horses
Quantitative peptide-binding motifs of MHC class I alleles provide a valuable tool to efficiently identify putative T cell epitopes. Detailed information on equine MHC class I alleles is still very limited, an...
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Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
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Impact of pre-adapted HIV transmission
Jonathan Carlson and colleagues report that pre-adaptation of HIV to a recipient's major histocompatibility complex class I alleles impairs immune control of the virus.
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Open AccessErratum: RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection
Nature Communications 6: Article number: 10224 (2015); Published: 21 December 2015; Updated: 9 March 2016 In Fig. 5 of this article, the three dot plots in the first row of panel a contain black numerical labe...
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Characterization of the peptide binding specificity of the HLA class I alleles B*38:01 and B*39:06
B*38:01 and B*39:06 are present with phenotypic frequencies <2 % in the general population, but are of interest as B*39:06 is the B allele most associated with type 1 diabetes susceptibility and 38:01 is most ...
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Open AccessAn ontology for major histocompatibility restriction
MHC molecules are a highly diverse family of proteins that play a key role in cellular immune recognition. Over time, different techniques and terminologies have been developed to identify the specific type(s)...
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Open AccessRSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection
In animal models, resident memory CD8+ T (Trm) cells assist in respiratory virus elimination but their importance in man has not been determined. Here, using experimental human respiratory syncytial virus (RSV...
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The common equine class I molecule Eqca-1*00101 (ELA-A3.1) is characterized by narrow peptide binding and T cell epitope repertoires
Here we describe a detailed quantitative peptide-binding motif for the common equine leukocyte antigen (ELA) class I allele Eqca-1*00101, present in roughly 25 % of Thoroughbred horses. We determined a prelimi...
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Open AccessAllergy-associated T cell epitope repertoires are surprisingly diverse and include non-IgE reactive antigens
We recently identified T cell epitopes associated with human allergic responses. In a majority of cases, responses focused on a few immunodominant epitopes which can be predicted on the basis of MHC binding ch...
