-
Article
Open AccessThe genome of the arapaima (Arapaima gigas) provides insights into gigantism, fast growth and chromosomal sex determination system
We have sequenced the genome of the largest freshwater fish species of the world, the arapaima. Analysis of gene family dynamics and signatures of positive selection identified genes involved in the specific a...
-
Article
Open AccessApplication of the Transcriptional Disease Signature (TDSs) to Screen Melanoma-Effective Compounds in a Small Fish Model
Cell culture and protein target-based compound screening strategies, though broadly utilized in selecting candidate compounds, often fail to eliminate candidate compounds with non-target effects and/or safety ...
-
Article
Open AccessGerm cell and tumor associated piRNAs in the medaka and **phophorus melanoma models
A growing number of studies report an abnormal expression of Piwi-interacting RNAs (piRNAs) and the piRNA processing enzyme Piwi in many cancers. Whether this finding is an epiphenomenon of the chaotic molecul...
-
Article
Chromosomal Organization, Evolutionary Relationship, and Expression of Zebrafish GnRH Family Members
Multiple forms of gonadotropin-releasing hormone (GnRH) are found in different vertebrates. In this study, we have cloned cDNA encoding the full-length gnrh3 and gnrh2 from zebrafish brain and characterized their...
-
Article
Correction: Vertebrate genome evolution and the zebrafish gene map
Nature Genet. 18, 345–349 (1998).
