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  1. Article

    Author Correction: PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

    Wesley K. Kroeze, Maria F. Sassano, **-** Huang… in Nature Structural & Molecular Biology (2024)

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    TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

    G-protein-coupled receptors (GPCRs) remain major drug targets, despite our incomplete understanding of how they signal through 16 non-visual G-protein signal transducers (collectively named the transducerome) ...

    Reid H. J. Olsen, Jeffrey F. DiBerto, Justin G. English… in Nature Chemical Biology (2020)

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    Article

    Structural determinants of 5-HT2B receptor activation and biased agonism

    Serotonin (5-hydroxytryptamine; 5-HT) receptors modulate a variety of physiological processes ranging from perception, cognition and emotion to vascular and smooth muscle contraction, platelet aggregation, gas...

    John D. McCorvy, Daniel Wacker, Sheng Wang… in Nature Structural & Molecular Biology (2018)

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    Article

    Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

    D2 dopamine receptor ligands biased for b-arrestin recruitment were developed based on a receptor homology model that identified conserved ligand contacts within the TM5 and EL2 regions as important for biased...

    John D McCorvy, Kyle V Butler, Brendan Kelly, Katie Rechsteiner… in Nature Chemical Biology (2018)

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    Article

    In silico design of novel probes for the atypical opioid receptor MRGPRX2

    High-throughput screening identifies opioid compounds and prodynorphin-derived peptide agonists of the G-protein-coupled receptor MRGPRX2 and informs a homology model that is used for in silico screening to find ...

    Katherine Lansu, Joel Karpiak, **g Liu, **-** Huang… in Nature Chemical Biology (2017)

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    Article

    PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

    Roth and colleagues have developed PRESTO-Tango, a new open-source platform for high-throughput screening of the entire human nonolfactory GPCRome, and they show how it can be used to identify new ligands for ...

    Wesley K Kroeze, Maria F Sassano, **-** Huang… in Nature Structural & Molecular Biology (2015)