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within John D. McCorvy Remove this filter Chemistry Remove this filter Bioorganic Chemistry Remove this filter Chemistry/Food Science, general Remove this filter

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  1. No Access

    Article

    TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

    G-protein-coupled receptors (GPCRs) remain major drug targets, despite our incomplete understanding of how they signal through 16 non-visual G-protein signal transducers (collectively named the transducerome) ...

    Reid H. J. Olsen, Jeffrey F. DiBerto, Justin G. English… in Nature Chemical Biology (2020)

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    Article

    Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

    D2 dopamine receptor ligands biased for b-arrestin recruitment were developed based on a receptor homology model that identified conserved ligand contacts within the TM5 and EL2 regions as important for biased...

    John D McCorvy, Kyle V Butler, Brendan Kelly, Katie Rechsteiner… in Nature Chemical Biology (2018)

  3. No Access

    Article

    In silico design of novel probes for the atypical opioid receptor MRGPRX2

    High-throughput screening identifies opioid compounds and prodynorphin-derived peptide agonists of the G-protein-coupled receptor MRGPRX2 and informs a homology model that is used for in silico screening to find ...

    Katherine Lansu, Joel Karpiak, **g Liu, **-** Huang… in Nature Chemical Biology (2017)