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Article
Semi-annual oscillations in Saturn’s low-latitude stratospheric temperatures
Both Earth and Jupiter have equatorial oscillations in their atmospheres, with two-year and four-year periodicity respectively. Two groups working independently now report a related phenomenon on Saturn. Orton et...
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Article
Putting chirality to work: the strategy of chiral switches
Chiral switches are chiral drugs that have already been claimed, approved and marketed as racemates or as mixtures of stereoisomers, but have since been redeve...
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Article
The pharmacogenetic basis of adverse drug reactions
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Article
Auditing ART success rates: It can be done
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Chapter
Drug Conjugation: Diversity and Biological Significance
The first conjugation reaction, the conversion of benzoic acid to hippuric acid, was reported in 1842. Subsequent research lead to the discovery of major pathways involving conjugation with glucuronic acid, su...
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Article
Images of aurorae on Jupiter from H+3 emission at 4 μm
SINCE their discovery by Voyager1, aurorae on Jupiter have been regularly observed over the past ten years, from space at ultraviolet wavelengths2 and from the Earth in the thermal infrared band3 (8–13 μm). The u...
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Article
The Contemporary Marriage and Fertility Revolutions in the West the Explanations Provided by Australian Participants
The last half century has witnessed both in Australia, and elsewhere in the West, first a “baby boom” (and marriage boom) and then a “baby bust” (and marriage bust). Economists, demographers, sociologists and ...
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Chapter
Pitfalls in the Enantioselective Analysis of Chiral Drugs
There is currently considerable interest in the stereochemical aspects of biochemical pharmacology, largely originating from analytical developments permitting the determination of the enantiomeric composition...
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Article
Book reviews and bibliography
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Chapter
Approaches for Determining Ethylenediamine and its Metabolites: Use of [14C]- and [D4]-Ethylenediamine
Ethylenediamine (1,2-diaminoethane) is a small, highly basic molecule of some industrial importance. It is used in the manufacture of various polymers, resins and dyestuffs, is present in cutting oils and wett...
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Article
Tentative confirmation of an aurora on Uranus
There have been three recent reports of the detection of Lyα radiation (due to atomic hydrogen, H, at wavelength 1,216 Å) from Uranus by means of the International Ultraviolet Explorer (IUE) satellite. The interp...
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Chapter
Isolation and Characterization of Amino Acid and Sugar Conjugates of Xenobiotic Carboxylic Acids
The carboxyl group in xenobiotics such as certain drugs and pesticides may be conjugated with glucuronic acid, glycine, glutamine or taurine. A logical system, developed for excreta but of general applicabilit...
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Article
The 20-µm brightness temperature of the unilluminated side of Saturn's rings
The 20-µm brightness temperature of the unilluminated (north) side of Saturn's rings is reported here to be 56±1 K. This measurement, together with previous measurements of the rings at 20 µm, shows that the b...
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Article
Drug metabolism in ”exotic” animals
Most studies of foreign compound metabolism have been performed in a restricted number of common laboratory animal species. The examination of animals not commonly found in the laboratory may aid in understand...
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Article
The fate of dichlorophen in the rat
The fate of [l4C] dichlorophen (2,2’-dihydroxy-5,5’-dichlorodiphenyl [14C]methane) has been studied in the rat. The compound was well absorbed after oral examination, with 78% of the dose excreted in the urine an...
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Article
British Drug Metabolism group
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Article
Effect of High Pressures of Pure Oxygen on Tissues
IN the course of some investigations carried out in the Botany School, Cambridge, between 1927 and 1930, it was found that pressures of the order of 5 atmospheres and more of pure oxygen had an unexpected effe...
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Article
Further Evidence of Polar Movement of Nutrients in Plants
IN two earlier papers I showed that there was good evidence for postulating polar rather than transverse movement of materials in plants1a,b. This conclusion was supported by later work on the movement of fluores...
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Article
Persistence of Tomato Aucuba Mosaic Virus in Dried Leaf Tissue
IN December 1934, in order to keep in a convenient form some material of the strain of tomato aucuba mosaic virus with which I had been working at Rothamsted Experimental Station, some leaves of infected tomat...
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Article
A New Virus Disease of Tomatoes
IN the 1944 growing season a number of tomato plants grown as an outdoor crop under commercial conditions were noted as being infected with a virus disease. Subsequent work on this disease has revealed that it...
