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Article
Effect of click-polarity on abnormality of intraoperatively monitored brainstem acoustic evoked potentials
The configuration of brainstem acoustic evoked potentials (BAEP) is influenced by the type of click stimuli used and may thus affect detectability of abnormalities. In a group of 19 patients with lesions in th...
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Article
German-Austrian Scape Occupying Cerebellar Infarction Study (GASCIS): study design, methods, patient characteristics
An open prospective multicentric therapeutic trial to determine the timing and type of therapeutic intervention in patients presenting with secondary deterioration following cerebellar stroke is described. Acc...
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Article
Ganglioglioma: a detailed histopathological and immunohistochemical analysis of 61 cases
Gangliogliomas are tumors composed of intimately admixed neuronal and glial components and account for approximately 1% of all brain tumors. Here we report the histopathological findings in 61 gangliogliomas. ...
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Article
Hippocampal loss of the GABAA receptor α1 subunit in patients with chronic pharmacoresistant epilepsies
Alterations of gamma aminobutyric acid (GABA)-mediated neurotransmission have been implicated in the pathogenesis of epilepsies. Here we examine the distribution of the GABAA receptor in the hippocampus of 78 sur...
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Article
Titanium intervertebral disc and instrumentation for fusion in anterior cervical discectomy. Technical note
A new titanium intervertebral disc for fusion in anterior cervical discectomy is described. The advantages of the device, apart from avoidance of graft explanation, include biocompatibility, simple instrumenta...
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Article
Altered distribution of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit GluR2(4) and the N-methyl-d-aspartate receptor subunit NMDAR1 in the hippocampus of patients with temporal lobe epilepsy
In patients with therapy-refractory temporal lobe epilepsy (TLE), alterations of glutamate receptors have been proposed as a mechanism for enhanced excitability. Using commercially available monoclonal antibo...
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Article
Diagnosis and treatment of frontobasal skull fractures
During a five-year-period (January 1990 to December 1994) a total of 67 patients were operated on for frontobasal skull fractures. The indication for surgical treatment was based on the evidence of fractures e...
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Article
Surgical management of brain-stem cavernomas
We present a series of seven patients who were operated on for symptomatic brain-stem cavernomas. The following approaches were used: medial suboccipital (N = 4), lateral suboccipital (N = 1), subtemporal-tran...
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Article
PTEN mutations in gliomas and glioneuronal tumors
Cytogenetic and loss of heterozygosity studies have suggested the presence of at least one tumor suppressor gene on chromosome 10 involved in the formation of high grade gliomas. Recently, the PTEN gene, also ter...
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Article
An increase of hippocampal calretinin-immunoreactive neurons correlates with early febrile seizures in temporal lobe epilepsy
Numerous studies indicate that initial precipitating injuries (IPI) such as febrile seizures during early childhood may play a pivotal role in the pathogenesis of temporal lobe epilepsy (TLE) and Ammon’s horn...
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Article
The CD34 epitope is expressed in neoplastic and malformative lesions associated with chronic, focal epilepsies
The etiology and pathogenesis of complex focal lesions associated with chronic, intractable epilepsy are largely unknown. Some data indicate that malformative changes of the central nervous system may preceed...
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Article
Quantitative analysis of NF1 and OMGP gene transcripts in sporadic gliomas, sporadic meningiomas and neurofibromatosis type 1-associated plexiform neurofibromas
The close association of neurofibromatosis type 1 (NF1) with gliomas raises the question of whether the NF1 gene may be involved in the pathogenesis of sporadic astrocytic brain tumors. However, no frequent muta...
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Article
Functional evidence for a role of combined CDKN2A (p16-p14ARF)/CDKN2B (p15) gene inactivation in malignant gliomas
Homozygous chromosome 9p deletions in gliomas commonly include the CDKN2A and CDKN2B genes, which code for the structurally highly homologous cdk inhibitors/tumor suppressors p16 and p15, respectively. Alternati...
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Article
Alternative splicing of the p15 cdk inhibitor in glioblastoma multiforme
Thirty-four to fifty-six percent of malignant gliomas harbor homozygous co-deletions of the INK4a p16-p14ARF and INK4b p15 tumor suppressor genes. Recently, an alt...
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Article
Postsurgical outcome of children and adolescents with medically refractory frontal lobe epilepsies
Objects: In the adult population surgical treatment is generally less favorable for refractory frontal lobe epilepsy (FLE) than for temporal lobe epilepsy (TLE). Predictive factors and outcome of...
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Article
Alterations of INK4a p16—p14ARF /INK4b p15 Expression and Telomerase Activation in Meningioma Progression
Dysregulation of cell cycle progression and telomerase activation have been implicated in malignant tumor progression as well as in the evasion of senescence and immortalization. We have investigated expressio...
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Article
Combined Surgery, Radiation, and PCV Chemotherapy for Astrocytomas Compared to Oligodendrogliomas and Oligoastrocytomas WHO Grade III
The time to tumor progression (TTP), time to death (TTD) and complications were studied prospectively in a cohort of patients treated by surgery and adjuvant radio- and intensified PCV chemotherapy for astrocy...
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Article
Mutational and expression analysis of the reelin pathway components CDK5 and doublecortin in gangliogliomas
Gangliogliomas represent highly differentiated glioneuronal tumors frequently occurring in young patients with focal epilepsies. Dysplastic neurons are a neuropathological hallmark of this neoplasm. Here, we ...
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Article
Conditional Expression of the Tumor Suppressor P16 in a Heterotopic Glioblastoma Model Results in Loss of PRB Expression
We have expressed the tumor suppressor p16 under the control of a tetracycline-sensitive promoter in two human glioblastoma cell lines which do not contain endogenous p16. Ectopic p16 expression led to a stabl...
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Article
Cellular pathology of amygdala neurons in human temporal lobe epilepsy
The amygdala complex substantially contributes to the generation and propagation of focal seizures in patients suffering from temporal lobe epilepsy (TLE). A cellular substrate for increased excitability in th...
