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Article
PGC-1β modulates statin-associated myotoxicity in mice
Statins inhibit cholesterol biosynthesis and lower serum LDL-cholesterol levels. Statins are generally well tolerated, but can be associated with potentially life-threatening myopathy of unknown mechanism. We ...
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Article
IFN-β-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositis
Dermatomyositis (DM) is an autoimmune disease associated with enhanced type I interferon (IFN) signalling in skeletal muscle, but the mechanisms underlying muscle dysfunction and inflammation perpetuation rema...
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Article
Endothelial function does not improve with high-intensity continuous exercise training in SHR: implications of eNOS uncoupling
Exercise training is a well-recognized way to improve vascular endothelial function by increasing nitric oxide (NO) bioavailability. However, in hypertensive subjects, unlike low- and moderate-intensity exerci...
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Article
Open AccessThe transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defence in skeletal muscles
The transcriptional coregulators PGC-1α and PGC-1β modulate the expression of numerous partially overlap** genes involved in mitochondrial biogenesis and energetic metabolism. The physiological role of PGC-1...
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Pathogenic Implications of Human Mitochondrial Aminoacyl-tRNA Synthetases
Mitochondria are considered as the powerhouse of eukaryotic cells. They host several central metabolic processes fueling the oxidative phosphorylation pathway (OXPHOS) that produces ATP from its precursors ADP...
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Article
Open AccessAvian erythrocytes have functional mitochondria, opening novel perspectives for birds as animal models in the study of ageing
In contrast to mammalian erythrocytes, which have lost their nucleus and mitochondria during maturation, the erythrocytes of almost all other vertebrate species are nucleated throughout their lifespan. Little ...
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Article
Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension
We assessed the time courses of mitochondrial biogenesis factors and respiration in the right ventricle (RV), gastrocnemius (GAS), and left ventricle (LV) in a model of pulmonary-hypertensive rats. Monocrotali...
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Article
Natural regulatory T cells control the development of atherosclerosis in mice
Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the artery wall and leads to myocardial infarction and stroke1,2. Here, we show that naturally arising CD4+CD25+ regulatory T...
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Article
Evaluation of quantitative and qualitative aspects of mitochondrial function in human skeletal and cardiac muscles
Techniques and protocols of assessment of mitochondrial properties are of physiological and physiopathological important significance. A precise knowledge of the advantages and limitations of the different pro...
