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Article
Understanding Spondyloarthritis Pathogenesis: The Promise of Single-Cell Profiling
Single-cell profiling, either in suspension or within the tissue context, is a rapidly evolving field. The purpose of this review is to outline recent advancements and emerging trends with a specific focus on ...
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Article
Twenty Years of SPARTAN: From Inception to Impact (SPARTAN 2023 Annual Meeting Proceedings)
This review takes a look at the past, present, and future of SPARTAN, the Spondyloarthritis Research and Treatment Network, an organization of North American healthcare professionals dedicated to advancing res...
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Article
Activity of axial spondyloarthritis after one year of anti-tumor necrosis factor therapy among patients with inflammatory bowel diseases
The disease activity of axSpA after initiating anti-TNF agents for inflammatory bowel diseases (IBD) is poorly understood. We sought to examine the disease activity of axial spondyloarthritis (axSpA) after ini...
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Article
Open AccessSAPHO—a diagnosis to consider in patients with refractory costochondritis
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare, heterogeneous, self-limited disease of unknown etiology. It involves progressive bone and joint damage, and skin and bone les...
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Article
Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci
Genetic studies have revealed that autoimmune susceptibility variants are over-represented in memory CD4+ T cell regulatory elements1–3. Understanding how genetic variation affects gene expression in different T ...
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Article
Thinking beyond pannus: a review of retro-odontoid pseudotumor due to rheumatoid and non-rheumatoid etiologies
Retro-odontoid pseudotumor, or mass-like retro-odontoid soft tissue thickening, is an uncommon but important imaging finding that may be associated with rheumatoid arthritis, crystal deposition diseases, as we...
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Chapter
Spondyloarthritis
The term spondyloarthritis (SpA) defines a family of diseases with overlap** clinical features that reflect shared genetic risk factors and pathophysiology. Inflammation of the spine is a core feature of the...
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Article
Open AccessAlpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis
Inflammatory bowel disease (IBD) are heterogenous disorders of the gastrointestinal tract caused by a spectrum of genetic and environmental factors. In mice, overlap** regions of chromosome 3 have been assoc...
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Article
Open AccessAuthor Correction: Towards an arthritis flare-responsive drug delivery system
In the original version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support from the National Football League Play...
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Article
Open AccessHistone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts
Multiple regulatory mechanisms control osteoblast differentiation and function to ensure unperturbed skeletal formation and remodeling. In this study we identify histone lysine-specific demethylase 1(LSD1/KDM1...
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Article
Open AccessTowards an arthritis flare-responsive drug delivery system
Local delivery of therapeutics for the treatment of inflammatory arthritis (IA) is limited by short intra-articular half-lives. Since IA severity often fluctuates over time, a local drug delivery method that t...
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Article
Immune cell profiling to guide therapeutic decisions in rheumatic diseases
Immune cell profiling to provide prognostic information and predict treatment responses is not yet part of clinical rheumatology practice
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Article
Protein microarrays for multiplex analysis of signal transduction pathways
We have developed a multiplexed reverse phase protein (RPP) microarray platform for simultaneous monitoring of site-specific phosphorylation of numerous signaling proteins using nanogram amounts of lysates der...
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Article
Scratching the (T cell) surface
Using a genome-scale approach to study transcription levels in a human CD8+ T-cell clone, a recent study has suggested that the repertoire of molecules on the surface of T cells is close to being completely chara...
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Article
CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
Mature donor T cells cause graft-versus-host disease (GVHD), but they are also the main mediators of the beneficial graft-versus-tumor (GVT) activity of allogeneic bone marrow transplantation. Suppression of G...
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Article
Autoimmune diseases: genes, bugs and failed regulation
In this Overview, common themes of the accompanying News & Views on RA, SLE, IDDM, thyroiditis and MS are discussed. A unifying concept for the development of these and other autoimmune diseases should incorpo...
