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  1. No Access

    Chapter

    Molecular Analysis of the Human Interleukin-2 Receptor

    Complete expression of the human immune response requires the generation of activated T cells1. This activation sequence is initiated by an interaction of antigen with specific receptors present on the membrane o...

    Warner C. Greene, Joel M. Depper… in Lymphoproliferative Diseases: Pathogenesis… (1985)

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    Chapter

    Molecular Cloning and Expression of cDNAS Encoding the Human Interleukin-2 Receptor

    We have identified cDNAs encoding the human interleu- kin-2 (IL-2) receptor from a cDNA library constructed from HUT-102B2 cell mRNA, and have expressed them in eukaryotic cells. Based on the deduced amino aci...

    Warren J. Leonard, Joel M. Depper, Gerald R. Crabtree, Stuart Rudikoff… in Immune Regulation (1985)

  3. No Access

    Chapter

    Interleukin-2 Receptors

    Interleukin-2 (IL-2) is a lymphokine synthesized by some T-cells following activation. Resting T-cells do not express IL-2 receptors but receptors are rapidly expressed on T-cells following the interaction of ...

    Thomas A. Waldmann, Warren J. Leonard, Joel M. Depper, Martin Kronke… in Human T Cell Clones (1985)

  4. No Access

    Article

    Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

    We have purified the human T-cell growth factor (interleukin-2) receptor and have cloned, sequenced and expressed cDNAs corresponding to this receptor. We identify one gene, but two interleukin-2 receptor mRNA...

    Warren J. Leonard, Joel M. Depper, Gerald R. Crabtree, Stuart Rudikoff… in Nature (1984)

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    Chapter

    A Monoclonal Antibody to the Human Receptor for T Cell Growth Factor

    T cell growth factor (TCGF or interleukin-2) is a 14800-dalton glycoprotein hormone which is essential for a normal immune response. It has been extensively reviewed previously (Smith, 1980; Ruscetti and Gallo...

    Warren J. Leonard, Joel M. Depper, Thomas A. Waldmann… in Monoclonal Antibodies to Receptors (1984)

  6. No Access

    Article

    A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor

    T-cell growth factor (TCGF or interleukin-2) is an inducible glycoprotein hormone of molecular weight 15,000 (ref. 1) synthesized and secreted by T lymphocytes following activation with antigen or mitogen2,3. TCG...

    Warren J. Leonard, Joel M. Depper, Takashi Uchiyama, Kendall A. Smith… in Nature (1982)