20 Result(s)

Article

IL-27 gives a good gut feeling about immune regulation

Regulatory T (T_reg) cells maintain the balance between immune protection and pathology. Research has now found that intestinal T_reg cells produce IL-27 to restrain T_H17 cell-mediated immune responses, effectively...

Emily R. Siniscalco, Joe Craft in Nature Immunology (2023)

Article

Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function

Activated CD4 T cells proliferate rapidly and remodel epigenetically before exiting the cell cycle and engaging acquired effector functions. Metabolic reprogramming from the naive state is required throughout ...

Will Bailis, Justin A. Shyer, Jun Zhao, Juan Carlos Garcia Canaveras… in Nature (2019)

Article

T_FH cells progressively differentiate to regulate the germinal center response

Craft and colleagues show that follicular helper T cells progress through transcriptionally and functionally distinct stages that provide specific signals for germinal center regulation.

Jason S Weinstein, Edward I Herman, Begoña Lainez, Paula Licona-Limón… in Nature Immunology (2016)

Article

Production of IL-10 by CD4⁺ regulatory T cells during the resolution of infection promotes the maturation of memory CD8⁺ T cells

The precise factors that control effective memory formation by T cells are unclear. Kaech et al. demonstrate that regulatory T cell–produced IL-10 is critical for the generation of CD8⁺ memory cells.

Brian J Laidlaw, Weiguo Cui, Robert A Amezquita, Simon M Gray… in Nature Immunology (2015)

Article

PTENtiating autoimmunity through T_reg cell deregulation

Regulatory T cells require the phosphatase PTEN to maintain suppressive function in homeostatic conditions through preserved expression of CD25 and the transcription factor Foxp3.

John P Ray, Joe Craft in Nature Immunology (2015)

Article

Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation

Several unconventional T cell populations, including γδ T cells and regulatory T cells, are selected by recognition of self antigen in the thymus. Craft and colleagues add T_H-17 cells to the list of T cell subset...

Benjamin R Marks, Heba N Nowyhed, **-Young Choi, Amanda C Poholek… in Nature Immunology (2009)

Article

Resistance to Development of Collagen-Induced Arthritis in C57BL/6 Mice Is Due to a Defect in Secondary, but Not in Primary, Immune Response

Collagen-induced arthritis (CIA) is a rodent model of human rheumatoid arthritis. Mice of the H-2^q (DBA/1J) background are highly susceptible to disease whereas mice of the H-2^b (C57BL/6, B6) background are resis...

Meng Pan, Insoo Kang, Joe Craft, Zhinan Yin in Journal of Clinical Immunology (2004)

Article

γδ T cells in autoimmunity

γδ T cells likely play a critical role in the host defenses, and recent evidence has indicated they are important in regulation of the immune response after pathogen challenge. Data are also accumulating that ...

Zhinan Yin, Joe Craft in Springer Seminars in Immunopathology (2000)

Article

Autoreactive T cells in murine lupus

The conventional paradigm to explain systemic lupus erythematosus (SLE) is that disease results from tissue deposition of pathogenic autoantibodies and immune complexes, secondary to activation of autoreactive...

Joe Craft, Stanford Peng, Takao Fujii, Masato Okada… in Immunologic Research (1999)

Chapter

Lessons from Knockout and Transgenic Lupus-Prone Mice

Inbred mice have provided the majority of knowledge regarding the pathogenesis of lupus. Their ease of use relates predominately to their more accessible immune organs, greater genetic homogeneity, and more pr...

Stanford L. Peng, Joe Craft in Lupus (1999)

Article

Scleroderma: A disease related to damaged proteins?

Tissue ischemia generates potentially immunogenic peptides of autoantigens in the autoimmune disease, scleroderma.

Stanford L. Peng, Saeed Fatenejad, Joe Craft in Nature Medicine (1997)

Article

T cells in murine lupus: propagation and regulation of disease

MRL/Mp-lpr/lpr mice develop a spontaneous lupus syndrome, including hypergammaglobulinemia, autoantibodies, glomerulonephritis, and lymphadenopathy. To investigate the role of lymphocyte subsets in the pathogenes...

Stanford L. Peng, Joe Craft in Molecular Biology Reports (1996)

Article

Nucleotide sequence and genomic structure analyses of the p70 subunit of the human Ku autoantigen: evidence for a family of genes encoding Ku (p70)-related polypeptides

cDNA encoding the p70 polypeptide subunit of the human Ku autoantigen was isolated. In vitro expression analysis of the cDNA demonstrates that it encodes the entire open reading frame. Nucleotide sequence anal...

Andrew J. Griffith, Joe Craft, Janine Evans, Tsuneyo Mimori… in Molecular Biology Reports (1992)

Article

New RNPs of higher eukaryotes

Joe Craft, Heidi Gold in Molecular Biology Reports (1990)

Article

Higher order structure is present in the yeast nucleus: autoantibody probes demonstrate that the nucleolus lies opposite the spindle pole body

A panel of sera from 892 autoimmune patients was screened by indirect immunofluorescence on mammalian cells. Seventy-three sera were identified that recognize the nucleolus. Three of these sera appear to stain...

Charles H. Yang, Eric J. Lambie, John Hardin, Joe Craft, Michael Snyder in Chromosoma (1989)