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Article
IL-27 gives a good gut feeling about immune regulation
Regulatory T (Treg) cells maintain the balance between immune protection and pathology. Research has now found that intestinal Treg cells produce IL-27 to restrain TH17 cell-mediated immune responses, effectively...
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Article
Author Correction: Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function
Activated CD4 T cells proliferate rapidly and remodel epigenetically before exiting the cell cycle and engaging acquired effector functions. Metabolic reprogramming from the naive state is required throughout ...
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Article
TFH cells progressively differentiate to regulate the germinal center response
Craft and colleagues show that follicular helper T cells progress through transcriptionally and functionally distinct stages that provide specific signals for germinal center regulation.
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Article
Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells
The precise factors that control effective memory formation by T cells are unclear. Kaech et al. demonstrate that regulatory T cell–produced IL-10 is critical for the generation of CD8+ memory cells.
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Article
PTENtiating autoimmunity through Treg cell deregulation
Regulatory T cells require the phosphatase PTEN to maintain suppressive function in homeostatic conditions through preserved expression of CD25 and the transcription factor Foxp3.
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Article
Open AccessAberrant expansion of CXCR5+ memory CD4 T cells in patients with systemic lupus erythematosus
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Erratum to: Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
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Article
Open AccessDysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
Interleukin (IL)-17 is a proinflammatory cytokine that is produced largely by a unique CD4+ T-helper (Th) subset called Th17 cells. The development of Th17 cells is suppressed by interferon (IFN)-γ produced by Th...
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Article
Correction: Corrigendum: Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation
Nat. Immunol. 10, 1125–1132 (2009); published online 6 September 2009; corrected after print 5 October 2009 In the version of this article initially published, two relevant papers are not cited. The following ...
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Article
Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation
Several unconventional T cell populations, including γδ T cells and regulatory T cells, are selected by recognition of self antigen in the thymus. Craft and colleagues add TH-17 cells to the list of T cell subset...
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Article
Resistance to Development of Collagen-Induced Arthritis in C57BL/6 Mice Is Due to a Defect in Secondary, but Not in Primary, Immune Response
Collagen-induced arthritis (CIA) is a rodent model of human rheumatoid arthritis. Mice of the H-2q (DBA/1J) background are highly susceptible to disease whereas mice of the H-2b (C57BL/6, B6) background are resis...
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Article
γδ T cells in autoimmunity
γδ T cells likely play a critical role in the host defenses, and recent evidence has indicated they are important in regulation of the immune response after pathogen challenge. Data are also accumulating that ...
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Article
Autoreactive T cells in murine lupus
The conventional paradigm to explain systemic lupus erythematosus (SLE) is that disease results from tissue deposition of pathogenic autoantibodies and immune complexes, secondary to activation of autoreactive...
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Chapter
Lessons from Knockout and Transgenic Lupus-Prone Mice
Inbred mice have provided the majority of knowledge regarding the pathogenesis of lupus. Their ease of use relates predominately to their more accessible immune organs, greater genetic homogeneity, and more pr...
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Article
Scleroderma: A disease related to damaged proteins?
Tissue ischemia generates potentially immunogenic peptides of autoantigens in the autoimmune disease, scleroderma.
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Article
T cells in murine lupus: propagation and regulation of disease
MRL/Mp-lpr/lpr mice develop a spontaneous lupus syndrome, including hypergammaglobulinemia, autoantibodies, glomerulonephritis, and lymphadenopathy. To investigate the role of lymphocyte subsets in the pathogenes...
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Article
Nucleotide sequence and genomic structure analyses of the p70 subunit of the human Ku autoantigen: evidence for a family of genes encoding Ku (p70)-related polypeptides
cDNA encoding the p70 polypeptide subunit of the human Ku autoantigen was isolated. In vitro expression analysis of the cDNA demonstrates that it encodes the entire open reading frame. Nucleotide sequence anal...
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Article
New RNPs of higher eukaryotes
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Article
Higher order structure is present in the yeast nucleus: autoantibody probes demonstrate that the nucleolus lies opposite the spindle pole body
A panel of sera from 892 autoimmune patients was screened by indirect immunofluorescence on mammalian cells. Seventy-three sera were identified that recognize the nucleolus. Three of these sera appear to stain...