-
Article
Open AccessRetirement age does not modify the association of prior working conditions with self-rated health and mortality in retirees: results from a prospective study of retired French workers
It is unclear whether retirement age can modify the association of working conditions with health and mortality in retirees who are no longer exposed to these conditions.
-
Article
Erratum: Clearance systems in the brain—implications for Alzheimer diseaser
Nature Reviews Neurology 11, 457–470 (2015) In the initially published version of this article, Figure 1 had an incomplete credit line. The correct credit line reads: Redrawn from Nedergaard, M. Garbage truck ...
-
Article
Open AccessThe Third French Alzheimer Plan: analysis of the influence of a national public health initiative on scientific research productivity and impact
The Third National Alzheimer Plan (2008–2012) was a major public health initiative in France that included €200 million of funding for research in Alzheimer disease and related disorders (AD). The aim of this ...
-
Article
Clearance systems in the brain—implications for Alzheimer disease
Accumulation of neurotoxic forms of amyloid-β (Aβ) and tau proteins is the pathological hallmark of Alzheimer disease (AD)
- ...
-
Article
Unemployment is associated with high cardiovascular event rate and increased all-cause mortality in middle-aged socially privileged individuals
To assess prospectively the association between employment status and cardiovascular health outcomes in socially privileged individuals.
-
Article
Open AccessAldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects
Aldosterone synthase inhibition provides the potential to attenuate both the mineralocorticoid receptor-dependent and independent actions of aldosterone. In vitro studies with recombinant human enzymes showed LCI...
-
Article
20-Year prevalence projections for dementia and impact of preventive policy about risk factors
Incidence of dementia increases sharply with age and, because of the increase in life expectancy, the number of dementia cases is expected to rise dramatically over time. Some studies suggest that controlling ...
-
Article
Renin Inhibitors and Cardiovascular and Renal Protection: An Endless Quest?
Renin-angiotensin system (RAS) blockade with angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) has become a major therapeutic approach in medicine since the end of the 1970...
-
Article
Mice chronically fed a westernized experimental diet as a model of obesity, metabolic syndrome and osteoporosis
Most studies in animals use diets with several features (for example low-fat, rich in micronutriments), likely to be strongly protective against chronic diseases.
-
Chapter
Patient Empowerment, Cybermedicine, and Citizen Education
Patient empowerment can be defined as “the increasing ability of patients to actively understand, participate in, and influence their health status.”1 Increased involvement of patients in the healthcare process i...
-
Article
Open AccessA computer decision aid for medical prevention: a pilot qualitative study of the Personalized Estimate of Risks (EsPeR) system
Many preventable diseases such as ischemic heart diseases and breast cancer prevail at a large scale in the general population. Computerized decision support systems are one of the solutions for improving the ...
-
Article
Functional consequences of angiotensin-converting enzyme gene polymorphism on N-acetyl-Ser-Asp-Lys-Pro degradation and angiotensin II production
Studies analyzing the biochemical and hemodynamic consequences of the insertion/deletion (I/D) polymorphism of the angiotensin I converting enzyme gene on angiotensin I and bradykinin metabolism have provided ...
-
Chapter
The ARTEMIS data and knowledge base for hypertension
In a medical care unit, computerized programs can be used to memorize patients’ individual records and profiles, to facilitate patient management and follow-up, to store medical knowledge and to provide facili...
-
Article
Identity of angiotensinogen precursors of rat brain and liver
Angiotensin modifies a number of functions of the central nervous system (CNS) including blood pressure regulation, thirst, and the secretion of the antidiuretic and adrenocorticotropic hormones. Whereas perip...
