34 Result(s)

Article

Multicenter evaluation of gut microbiome profiling by next-generation sequencing reveals major biases in partial-length metabarcoding approach

Next-generation sequencing workflows, using either metabarcoding or metagenomic approaches, have massively contributed to expanding knowledge of the human gut microbiota, but methodological bias compromises re...

Hugo Roume, Stanislas Mondot, Adrien Saliou… in Scientific Reports (2023)

Article

Long-term diosmectite use does not alter the gut microbiota in adults with chronic diarrhea

Diosmectite, a natural colloidal clay, has been used worldwide for a number of approved indications, including the treatment of chronic functional diarrhea. Here, we used high-resolution whole metagenome shotg...

Kévin Da Silva, Susie Guilly, Florence Thirion, Emmanuelle Le Chatelier… in BMC Microbiology (2022)

Article

Diet and gut microbiome interactions of relevance for symptoms in irritable bowel syndrome

While several studies have documented associations between dietary habits and microbiota composition and function in healthy individuals, no study explored these associations in patients with irritable bowel s...

Julien Tap, Stine Störsrud, Boris Le Nevé, Aurélie Cotillard, Nicolas Pons… in Microbiome (2021)

Article

High engraftment capacity of frozen ready-to-use human fecal microbiota transplants assessed in germ-free mice

The number of indications for fecal microbiota transplantation is expected to rise, thus increasing the needs for production of readily available frozen or freeze-dried transplants. Using shotgun metagenomics,...

Magali Berland, Julie Cadiou, Florence Levenez, Nathalie Galleron… in Scientific Reports (2021)

Article

Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications

Chronic immune-mediated diseases are rapidly expanding and notoriously difficult to cure. Altered relatively stable intestinal microbiota configurations are associated with several of these diseases, and with ...

Maarten Van de Guchte, Sebastian D. Burz, Julie Cadiou, Jiangbo Wu… in Microbiome (2020)

Article

Investigating host-microbiome interactions by droplet based microfluidics

Despite the importance of the mucosal interface between microbiota and the host in gut homeostasis, little is known about the mechanisms of bacterial gut colonization, involving foraging for glycans produced b...

Alexandra S. Tauzin, Mariana Rangel Pereira, Liisa D. Van Vliet… in Microbiome (2020)

Article

Late weaning is associated with increased microbial diversity and Faecalibacterium prausnitzii abundance in the fecal microbiota of piglets

In pig production systems, weaning is a crucial period characterized by nutritional, environmental, and social stresses. Piglets transition from a milk-based diet to a solid, more complex plant-based diet, and...

Francesca Romana Massacci, Mustapha Berri, Gaetan Lemonnier… in Animal Microbiome (2020)

Article

A Guide for Ex Vivo Handling and Storage of Stool Samples Intended for Fecal Microbiota Transplantation

Owing to the growing recognition of the gut microbiota as a main partner of human health, we are expecting that the number of indications for fecal microbiota transplantation (FMT) will increase. Thus, there i...

Sebastian D. Burz, Anne-Laure Abraham, Fernanda Fonseca… in Scientific Reports (2019)

Article

Correction: Amendments: Author Correction: A catalog of the mouse gut metagenome

Nat. Biotechnol. 33, 1103–1108 (2015); published online 28 September 2015; corrected after print 18 December 2018 In the version of this article initially published, the y-axis numbering in Figure 1 was high b...

Liang **ao, Qiang Feng, Suisha Liang, Si Brask Sonne, … in Nature Biotechnology (2019)

Article

Prediction of the intestinal resistome by a three-dimensional structure-based method

The intestinal microbiota is considered to be a major reservoir of antibiotic resistance determinants (ARDs) that could potentially be transferred to bacterial pathogens via mobile genetic elements. Yet, this ...

Etienne Ruppé, Amine Ghozlane, Julien Tap, Nicolas Pons… in Nature Microbiology (2019)

Article

High gastrointestinal microbial diversity and clinical outcome in graft-versus-host disease patients

Florent Malard, Cyrielle Gasc, Emilie Plantamura, Joël Doré in Bone Marrow Transplantation (2018)

Article

Fecal chromogranins and secretogranins are linked to the fecal and mucosal intestinal bacterial composition of IBS patients and healthy subjects

Altered fecal levels of chromogranins (Cg) and secretogranins (Sg) are demonstrated in irritable bowel syndrome (IBS), but their role in IBS pathophysiology remains unknown. This study aimed to determine if gr...

Johanna Sundin, Mats Stridsberg, Julien Tap, Muriel Derrien… in Scientific Reports (2018)

Article

Humans as holobionts: implications for prevention and therapy

The human gut microbiota is increasingly recognized for its important or even decisive role in health. As it becomes clear that microbiota and host mutually affect and depend on each other in an intimate relat...

Maarten van de Guchte, Hervé M. Blottière, Joël Doré in Microbiome (2018)

Article

Commensal gut bacteria modulate phosphorylation-dependent PPARγ transcriptional activity in human intestinal epithelial cells

In healthy subjects, the intestinal microbiota interacts with the host’s epithelium, regulating gene expression to the benefit of both, host and microbiota. The underlying mechanisms remain poorly understood, ...

Malgorzata Nepelska, Tomas de Wouters, Elsa Jacouton… in Scientific Reports (2017)

Article

A fibrolytic potential in the human ileum mucosal microbiota revealed by functional metagenomic

The digestion of dietary fibers is a major function of the human intestinal microbiota. So far this function has been attributed to the microorganisms inhabiting the colon, and many studies have focused on thi...

Orlane Patrascu, Fabienne Béguet-Crespel, Ludovica Marinelli… in Scientific Reports (2017)