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Article
Open AccessZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells
Development is generally viewed as one-way traffic of cell state transition from primitive to developmentally advanced states. However, molecular mechanisms that ensure the unidirectional transition of cell fa...
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Article
Open AccessThe Role of Chromatin Density in Cell Population Heterogeneity during Stem Cell Differentiation
We incorporate three-dimensional (3D) conformation of chromosome (Hi-C) and single-cell RNA sequencing data together with discrete stochastic simulation, to explore the role of chromatin reorganization in dete...