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Open AccessETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification
Dynamic changes in mechanical microenvironments, such as cell crowding, regulate lineage fates as well as cell proliferation. Although regulatory mechanisms for contact inhibition of proliferation have been ex...
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Article
Open AccessZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells
Development is generally viewed as one-way traffic of cell state transition from primitive to developmentally advanced states. However, molecular mechanisms that ensure the unidirectional transition of cell fa...
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Article
Physical activity buffers the effects of work-family conflict on work engagement through mastery recovery experience
Based on the Effort-Recovery model and the Job Demands-Resources model, this study investigated the moderated mediational process in which physical activity after work interacted with one type of work-family c...
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Article
Open AccessSingle-cell transcriptome of the mouse retinal pigment epithelium in response to a low-dose of doxorubicin
Cellular senescence of the retinal pigment epithelium (RPE) is thought to play an important role in vision-threatening retinal degenerative diseases, such as age-related macular degeneration (AMD). However, th...
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Article
Anti-photoaging activities of Sorbaria kirilowii ethanol extract in UVB-damaged cells
Sorbaria kirilowii (Regel) Maxim, a plant found in China, Korea, Japan, and east of Europe, is a common herb used for traditional medicinal purposes. However, its ability to prevent photoaging has not been studie...
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Article
Two-dimensional superlattice-like sheets of superparamagnetic graphene oxide/magnetic nanoparticle hybrids
Using a simple and facile method, we precisely controlled the two-dimensional layered array structure of graphene oxide (GO)–iron oxide (Fe3O4) nanoparticle hybrid multilayer films and investigated the correlatio...
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Article
Open AccessThe Role of Chromatin Density in Cell Population Heterogeneity during Stem Cell Differentiation
We incorporate three-dimensional (3D) conformation of chromosome (Hi-C) and single-cell RNA sequencing data together with discrete stochastic simulation, to explore the role of chromatin reorganization in dete...
