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Article
Open AccessETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification
Dynamic changes in mechanical microenvironments, such as cell crowding, regulate lineage fates as well as cell proliferation. Although regulatory mechanisms for contact inhibition of proliferation have been ex...
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Article
Open AccessZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells
Development is generally viewed as one-way traffic of cell state transition from primitive to developmentally advanced states. However, molecular mechanisms that ensure the unidirectional transition of cell fa...
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Article
Open AccessSingle-cell transcriptome of the mouse retinal pigment epithelium in response to a low-dose of doxorubicin
Cellular senescence of the retinal pigment epithelium (RPE) is thought to play an important role in vision-threatening retinal degenerative diseases, such as age-related macular degeneration (AMD). However, th...
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Article
Open AccessThe Role of Chromatin Density in Cell Population Heterogeneity during Stem Cell Differentiation
We incorporate three-dimensional (3D) conformation of chromosome (Hi-C) and single-cell RNA sequencing data together with discrete stochastic simulation, to explore the role of chromatin reorganization in dete...
