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  1. Article

    Open Access

    Glutathione prevents high glucose-induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS/TGFβ/SMAD pathway

    The activation of pancreatic stellate cells (PSCs) is the key mechanism of pancreatic fibrosis, which can lead to β-cell failure. Oxidative stress is an important risk factor for PSC activation. There is no di...

    Jitai Zhang, Juan Bai, Qian Zhou, Yuxin Hu, Qian Wang, Lanting Yang… in Cell Death & Disease (2022)

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  2. Article

    Open Access

    Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure

    Modern lifestyles have altered diet and metabolic homeostasis, with increased sugar intake, glycemic index, and prediabetes. A strong positive correlation between sugar consumption and diabetic incidence is re...

    Jitai Zhang, Hui An, Kaidi Ni, Bin Chen, Hui Li, Yanqin Li… in Cell Death & Disease (2019)

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  3. No Access

    Article

    Microarray Analysis of Differential Gene Expression Profile Between Human Fetal and Adult Heart

    Although many changes have been discovered during heart maturation, the genetic mechanisms involved in the changes between immature and mature myocardium have only been partially elucidated. Here, gene express...

    Zhimin Geng, Jue Wang, Lulu Pan, Ming Li, Jitai Zhang, Xueli Cai… in Pediatric Cardiology (2017)