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Open AccessMolecular basis for carrier protein-dependent amide bond formation in the biosynthesis of lincosamide antibiotics
In the biosynthesis of the lincosamide antibiotic celesticetin, the condensation enzyme CcbD generates the lincosamide pharmacophore by forming an amide bond between the carrier protein (CP)-tethered proline a...
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Article
Suitability and setup of next-generation sequencing-based method for taxonomic characterization of aquatic microbial biofilm
A robust and widely applicable method for sampling of aquatic microbial biofilm and further sample processing is presented. The method is based on next-generation sequencing of V4–V5 variable regions of 16S rR...
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Article
Open AccessC-C bond cleavage in biosynthesis of 4-alkyl-L-proline precursors of lincomycin and anthramycin cannot precede C-methylation
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Article
Open AccessNovel pathway of 3-hydroxyanthranilic acid formation in limazepine biosynthesis reveals evolutionary relation between phenazines and pyrrolobenzodiazepines
Natural pyrrolobenzodiazepines (PBDs) form a large and structurally diverse group of antitumour microbial metabolites produced through complex pathways, which are encoded within biosynthetic gene clusters. We ...
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Article
Open AccessSequence analysis of porothramycin biosynthetic gene cluster
The biosynthetic gene cluster of porothramycin, a sequence-selective DNA alkylating compound, was identified in the genome of producing strain Streptomyces albus subsp. albus (ATCC 39897) and sequentially charact...
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Article
Polyaniline Electrodes Containing Tri-Atomic Au/Pd Clusters: Effect of Ordering
Our atom-by-atom deposition method has been used to prepare hetero-tri-atomic clusters of Au 1 Pd ...
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Article
Effect of Structured Atomic Gold on Electrooxidation of Alcohols in Alkaline Medium
Survey of cyclic voltammograms of lower aliphatic alcohols in 1 M KOH recorded at electrodes containing atomic gold is presented. The atomically structured gold is placed in polyaniline, which is deposited on ...
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Article
Polyaniline Electrodes with Atomic Au n Pd1 Alloys: Oxidation of Methanol and Ethanol
The effect of addition of one atom of palladium to n atoms of gold (n = 1–5) dispersed in polyaniline electrodes, for the electrooxidation of methanol and ethanol in alkaline solution has been investigated. For c...
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Article
Atomic Clusters of Pd and AuNPdM in Polyaniline
The previously described cyclic pathway method for deposition of atomic metals has been used to create Pd1–6 atomic clusters and Au1–5Pd1 and Au1–4Pd2 bimetallic atomic clusters in polyaniline (PANI). The control...
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Article
Polyaniline-Supported Atomic Gold Electrodes: Comparison with Macro Electrodes
Under precisely controlled conditions, atomic gold electrodes with even or odd number of Au atoms per polyaniline repeat unit (Pt/PANI/Au N for 0 < N < 7) were prepared. Th...
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Article
Subunit–subunit interactions are weakened in mutant forms of acetohydroxy acid synthase insensitive to valine inhibition
In acetohydroxy acid synthase from Streptomyces cinnamonensis mutants affected in valine regulation, the impact of mutations on interactions between the catalytic and the regulatory subunits was examined using ye...
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Article
Organic semiconductors in potentiometric gas sensors
Solid-state potentiometric sensors based on the chemical modulation of the work function of organic semiconductors are discussed. The theory of the chemical work function modulation is briefly reviewed. There ...
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Article
Conducting polymers in electronic chemical sensors
Conducting organic polymers have found two main kinds of application in electronics so far: as materials for construction of various devices and as selective layers in chemical sensors. In either case, interac...
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Chapter
A Risk and Outcome Based Strategy for Justifying Characterization to Resolve Tank Waste Safety Issues
This report describes a risk-based decision-making strategy for determining characterization needs and resolving safety issues during the storage and remediation of radioactive waste stored in the 177 undergro...
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Article
Use of poly(octadec-1-ene-maleic anhydride) for interfacing bilayer membranes to solid supports in sensor applications
Spin-coated layer of poly(maleic anhydride) has been used to planarize photolithographically prepared substrates for bilayer-based sensors. It is possible to deposit the same material on top of the spun-on lay...
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Chapter
Solid State Potentiometric Sensors
It is more that fifteen years ago since the first integrated solid state electrochemical sensors have been described.1,2 These were ion-sensitive field effect transistors (ISFET) which belong to the group of elec...
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Book
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Chapter
Thermal Sensors
The first law of thermodynamics tells us that any process in which the internal energy of the system changes is accompanied by absorption or evolution of heat. The class of chemical sensors to be discussed in ...
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Chapter
Organic Polymer Films for Solid State Sensor Applications
Organic polymers from monolayers (∼50Å) to thin films (∼200 mm) are used in solid state chemical sensors for the purpose of introducing chemical selectivity to these devices. When a chemical species interacts ...
