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Article
A New Cell Signal Regulation Theory: Blocking the Signal from being Reactivated Before a New Activation
Currently, the concept of cell signal regulation has two basic steps: activation and deactivation. There are many activators of the signals in vivo (e.g., hormones, growth factors, signal cross-talk, etc.). Ac...
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Article
Open AccessAcute pressure on the sciatic nerve results in rapid inhibition of the wide dynamic range neuronal response
Acute pressure on the sciatic nerve has recently been reported to provide rapid short-term relief of pain in patients with various pathologies. Wide dynamic range (WDR) neurons transmit nociceptive information...
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Article
Open AccessA novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Chinese patients
Peutz-Jeghers syndrome (PJS) is caused by mutations in the tumor suppressor gene, STK11, and is characterized by gastrointestinal hamartomas, melanin spots on the lips, and an increased risk of develo** cancer.
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Article
Open AccessA new analgesic method, two-minute sciatic nerve press, for immediate pain relief: a randomized trial
Current analgesics have drawbacks such as delays in acquisition, lag-times for effect, and side effects. We recently presented a preliminary report of a new analgesic method involving a two-minute sciatic nerv...
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Article
Open AccessImmediate and short-term pain relief by acute sciatic nerve press: a randomized controlled trial
Despite much research, an immediately available, instantly effective and harmless pain relief technique has not been discovered. This study describes a new manipulation: a "2-minute sciatic nerve press", for r...
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Article
Primary 3-dimensional culture of mouse hepatocytes
Complex 3-dimensional structures with good functions have been obtained under the primary mixcoculture of mouse hepatocytes with mouse liver fibroblasts without serum. Albumin secretion is kept above 10 μg/106 ce...
