Skip to main content

and
  1. No Access

    Protocol

    Using Two-Dimensional Intact Mitochondrial DNA (mtDNA) Agarose Gel Electrophoresis (2D-IMAGE) to Detect Changes in Topology Associated with Mitochondrial Replication, Transcription, and Damage

    The study of mitochondrial DNA (mtDNA) integrity and how replication, transcription, repair, and degradation maintain mitochondrial function has been hampered due to the inability to identify mtDNA structural ...

    Jill E. Kolesar, Brett A. Kaufman in DNA Electrophoresis (2020)

  2. Article

    Correction: Corrigenda: MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

    Nat. Cell Biol. 14, 1336–1343 (2012); published online 25 November 2012; corrected after print 10 June 2015 In the version of this Letter originally published, a key funding source was omitted from the Acknowl...

    Karthik Mallilankaraman, César Cárdenas, Patrick J. Doonan in Nature Cell Biology (2015)

  3. Article

    Open Access

    Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints

    Mitochondrial DNA (mtDNA) deletions cause disease and accumulate during aging, yet our understanding of the molecular mechanisms underlying their formation remains rudimentary. Guanine-quadruplex (GQ) DNA stru...

    Dawei W Dong, Filipe Pereira, Steven P Barrett, Jill E Kolesar, Kajia Cao in BMC Genomics (2014)

  4. Article

    Erratum: MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

    Nat. Cell Biol. 14, 1336–1343 (2012); published online 25th November 2012; corrected online 30th November 2012 In the version of this Letter that was originally published, the affiliation of Jordi Molgó was er...

    Karthik Mallilankaraman, César Cárdenas, Patrick J. Doonan in Nature Cell Biology (2013)

  5. No Access

    Article

    MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

    The mitochondrial calcium uniporter (MCU) mediates calcium uptake by mitochondria and thus regulates cellular bioenergetics, but how MCU activity is modulated is not fully understood. Madesh, Foskett and colle...

    Karthik Mallilankaraman, César Cárdenas, Patrick J. Doonan in Nature Cell Biology (2012)

  6. No Access

    Article

    Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome

    Eric Shoubridge and colleagues report the identification of a mutation in the CCDC44 gene that is causal in a Leigh syndrome pedigree. The CCDC44 gene product, TACO1, is involved in mitochondrial translation and ...

    Woranontee Weraarpachai, Hana Antonicka, Florin Sasarman, Jürgen Seeger in Nature Genetics (2009)