152 Result(s)

Article

Development and validation of an automated Tomotherapy planning method for cervical cancer

This study aimed to develop an automated Tomotherapy (TOMO) planning method for cervical cancer treatment, and to validate its feasibility and effectiveness.

Feiru Han, Yi Xue, Sheng Huang, Tong Lu, Yining Yang, Yuanjie Cao… in Radiation Oncology (2024)

Article

A novel surgical scheme for hepatectomy in hepatocellular carcinoma patients with clinically significant portal hypertension

Clinically significant portal hypertension (CSPH) seriously affects the feasibility and safety of surgical treatment for hepatocellular carcinoma (HCC) patients. The aim of this study was to establish a new su...

Jia-zhou Ye, Hua-ze Lu, Can Zeng, Guo Lei, **ao-bo Wang, Jie Chen, Tao Bai… in BMC Cancer (2024)

Article

Integrated profiling identifies DXS253E as a potential prognostic marker in colorectal cancer

Increasing evidence suggests that DXS253E is critical for cancer development and progression, but the function and potential mechanism of DXS253E in colorectal cancer (CRC) remain largely unknown. In this stud...

Pu **ng, Hao Hao, Jiangbo Chen, **aowen Qiao, Tongkun Song… in Cancer Cell International (2024)

Article

Modulation of anti-cardiac fibrosis immune responses by changing M2 macrophages into M1 macrophages

Macrophages play a crucial role in the development of cardiac fibrosis (CF). Although our previous studies have shown that glycogen metabolism plays an important role in macrophage inflammatory phenotype, the ...

Shiqi Chen, Kan Wang, Zhengfeng Fan, Tingwen Zhou, Rui Li… in Molecular Medicine (2024)

Article

TACE combined Lenvatinib plus Camrelizumab versus TACE alone in efficacy and safety for unresectable hepatocellular carcinoma: a propensity score-matching study

To compare the efficacy and safety of transcatheter arterial chemoembolization (TACE) combined Lenvatinib plus Camrelizumab (TLC) in unresectable hepatocellular carcinoma (uHCC) with those of TACE alone .

Zhihong Tang, Tao Bai, Tao Wei, **aobo Wang, Jie Chen, Jiazhou Ye, Shangqi Li… in BMC Cancer (2024)

Article

Urolithin C suppresses colorectal cancer progression via the AKT/mTOR pathway

Urolithin families are gut-microbial metabolites of ellagic acid (EA). Although urolithin A (UA) and urolithin B (UB) were reported to have antiproliferative activities in cancer cells, the role and related me...

Haochi Yang, Binghuo Wu, Qi yang, Tian Tan, Dan Shang… in Journal of Natural Medicines (2024)

Article

Tanshinol ameliorates imiquimod-induced psoriasis by inhibiting M1 macrophage polarization through suppression of the notch signaling pathway

Psoriasis is a common immune-related chronic inflammatory skin disease, often accompanied by significant itching, and once diseased, the course of the disease lasts for most of the lifetime. Tanshinol (TAN) is...

Junhao Liu, Shuangshuang Yong, Sisi Yin… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2024)

Article

Correction: Inhibition of cIAP1/2 reduces RIPK1 phosphorylation in pulmonary endothelial cells and alleviate sepsis-induced lung injury and inflammatory response

**aoyu Liu, Yan Li, Weijian Zhang, Nan Gao, Jie Chen, Cheng **ao… in Immunologic Research (2024)

Article

Retraction Note: Numb inhibits epithelial-mesenchymal transition via RBP-Jκ-dependent Notch1/PTEN/FAK signaling pathway in tongue cancer

**-Yun Li, Wen-**ao Huang, **ao Zhou, Jie Chen, Zan Li in BMC Cancer (2024)

Article

UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5

Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that regulates ERα expression in triple-negative cancer (TNBC). This study aimed to explore the deubiquitination substrates of UCHL...

Juan Li, Yu Liang, Shijie Zhou, Jie Chen, Chihua Wu in Breast Cancer Research (2024)

Article

Prevalence of Neutralizing Autoantibodies Against Type I Interferon in a Multicenter Cohort of Severe or Critical COVID-19 Cases in Shanghai

We sought to explore the prevalence of type I interferon-neutralizing antibodies in a Chinese cohort and its clinical implications during the Omicron variant wave of SARS-CoV-2.

Dongling Shi, Jie Chen, Meng Zhao, Yuanjia Tang… in Journal of Clinical Immunology (2024)

Article

Lithium carbonate revitalizes tumor-reactive CD8⁺ T cells by shunting lactic acid into mitochondria

The steady flow of lactic acid (LA) from tumor cells to the extracellular space via the monocarboxylate transporter symport system suppresses antitumor T cell immunity. However, LA is a natural energy metaboli...

**gwei Ma, Liang Tang, Yaoyao Tan, **gxuan **ao, Keke Wei, **n Zhang… in Nature Immunology (2024)

Article

lncRNA-MIAT rs9625066 polymorphism could be a potential biomarker for ischemic stroke

Ischemic stroke (IS) is a common and serious neurological condition that is highly fatal but so far no early diagnostic markers are available. Myocardial infarction-associated transcript (MIAT) is a long non-c...

Yin-Hua Weng, Jie Chen, Wen-Tao Yu, Yan-** Luo, Chao Liu… in BMC Medical Genomics (2024)

Article

Autoinducer-2 promotes the colonization of Lactobacillus rhamnosus GG to improve the intestinal barrier function in a neonatal mouse model of antibiotic-induced intestinal dysbiosis

Human health is seriously threatened by antibiotic-induced intestinal disorders. Herein, we aimed to determine the effects of Autoinducer-2 (AI-2) combined with Lactobacillus rhamnosus GG (LGG) on the intestinal ...

Riqiang Hu, Ting Yang, Qing Ai, Yuan Shi, Yanchun Ji… in Journal of Translational Medicine (2024)

Article

Potential prognostic determinants for FET::CREB fusion-positive intracranial mesenchymal tumor

Intracranial mesenchymal tumor (IMT), FET::CREB fusion-positive is a provisional tumor type in the 2021 WHO classification of central nervous system tumors with limited information available. Herein, we describe ...

Frank M. Mezzacappa, Frankie K. Smith, Weiwei Zhang… in Acta Neuropathologica Communications (2024)

Article

Deciphering the gut microbiome of grass carp through multi-omics approach

Aquaculture plays an important role in global protein supplies and food security. The ban on antibiotics as feed additive proposes urgent need to develop alternatives. Gut microbiota plays important roles in t...

Ming Li, Hui Liang, Hongwei Yang, Qianwen Ding, Rui **a, Jie Chen… in Microbiome (2024)

Article

Publisher Correction: Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1

Li Zhou, Dongxiao Wu, Yabo Zhou, Dianheng Wang, Haixia Fu… in Nature Immunology (2023)

Article

Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1

Tumor-derived factors are thought to regulate thrombocytosis and erythrocytopenia in individuals with cancer; however, such factors have not yet been identified. Here we show that tumor cell-released kynurenin...

Li Zhou, Dongxiao Wu, Yabo Zhou, Dianheng Wang, Haixia Fu… in Nature Immunology (2023)

Article

Application of Nanopore Sequencing in the Diagnosis and Treatment of Pulmonary Infections

This review provides an in-depth discussion of the development, principles and utility of nanopore sequencing technology and its diverse applications in the identification of various pulmonary pathogens. We ex...

Jie Chen, Feng Xu in Molecular Diagnosis & Therapy (2023)

Article

Neuroprotective Effect of Hydrogen Sulfide Subchronic Treatment Against TBI-Induced Ferroptosis and Cognitive Deficits Mediated Through Wnt Signaling Pathway

Emerging evidence shows that targeting ferroptosis may be a potential therapeutic strategy for treating traumatic brain injury (TBI). Hydrogen sulfide (H₂S) has been proven to play a neuroprotective role in TBI, ...

Jie Chen, Zhennan Chen, Dongyu Yu, Yufei Yan… in Cellular and Molecular Neurobiology (2023)