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  1. Article

    Open Access

    Analysis of tumor abnormal protein expression and epidermal growth factor receptor mutation status in non-small cell lung cancer

    The level of tumor abnormal protein (TAP) level has a significant impact on tumor growth, recurrence, and metastasis. Previous studies have highlighted the influence of the mutations in exons 19 and 21 of the ...

    Yuanjun Cheng, Bin Chen, Qianru Fang, Guohui Zang, Jie Yao in Discover Oncology (2024)

  2. No Access

    Article

    Radiosensitization effect of quinoline-indole-schiff base derivative 10E on non-small cell lung cancer cells in vitro and in tumor xenografts

    Radioresistance is an inevitable obstacle in the clinical treatment of inoperable patients with non-small cell lung cancer (NSCLC). Combining treatment with radiosensitizers may improve the efficacy of radioth...

    Hongwei Liu, Qianqian Wang, Wanying Lan, Duanya Liu in Investigational New Drugs (2024)

  3. Article

    Open Access

    Novel artificial intelligence algorithms for diabetic retinopathy and diabetic macular edema

    Diabetic retinopathy (DR) and diabetic macular edema (DME) are major causes of visual impairment that challenge global vision health. New strategies are needed to tackle these growing global health problems, a...

    Jie Yao, Joshua Lim, Gilbert Yong San Lim, Jasmine Chiat Ling Ong in Eye and Vision (2024)

  4. Article

    Open Access

    A “twelve-section ultrasonic screening and diagnosis method” and management system for screening and treating neonatal congenital heart disease at the grassroots level in Tang County, Hebei Province, China

    To explore a method for screening and diagnosing neonatal congenital heart disease (CHD) applicable to grassroots level, evaluate the prevalence of CHD, and establish a hierarchical management system for CHD s...

    Yun Cui, **n-jian He, Le Wang, Yan-hui Fan, Jiao-yang Chen in BMC Pregnancy and Childbirth (2024)

  5. Article

    Open Access

    XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

    Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

    Qiu-Zhong Pan, **g-**g Zhao, Liang Liu in Signal Transduction and Targeted Therapy (2024)

  6. No Access

    Article

    Effect of cesarean section on the risk of autism spectrum disorders/attention deficit hyperactivity disorder in offspring: a meta-analysis

    This study was conducted to investigate the relationship between cesarean section (CS) offspring and autism spectrum disorders (ASD)/attention deficit hyperactivity disorder (ADHD).

    Meiling Chen, Yeting Lin, Chiyuan Yu, Rongrong Fu in Archives of Gynecology and Obstetrics (2024)

  7. No Access

    Article

    Meta-synthesis of qualitative studies on patient perceptions and requirements during the perioperative period of robotic surgery

    This research undertakes a comprehensive evaluation and amalgamation of patient experiences and requirements during the perioperative period of robot-assisted surgery (RS), with the goal of enriching clinical ...

    Shuang Wu, Chunzhi Yang, Liu He, Zhixuan Hu, Jie Yao in Journal of Robotic Surgery (2024)

  8. Article

    Open Access

    Association of cesarean section with asthma in children/adolescents: a systematic review and meta-analysis based on cohort studies

    Whether cesarean section (CS) is a risk factor for asthma in offspring is controversial. The purpose of this study was to investigate the association between CS and asthma in children/adolescents.

    Ziwei Zhong, Meiling Chen, Senjie Dai, Yu Wang, Jie Yao, Haojie Shentu in BMC Pediatrics (2023)

  9. Article

    Open Access

    Construction and validation of machine learning models for sepsis prediction in patients with acute pancreatitis

    This study aimed to construct predictive models for the risk of sepsis in patients with Acute pancreatitis (AP) using machine learning methods and compared optimal one with the logistic regression (LR) model a...

    Fei Liu, Jie Yao, Chunyan Liu, Songtao Shou in BMC Surgery (2023)

  10. Article

    Open Access

    Automatic analysis framework based on 3D-CT multi-scale features for accurate prediction of Ki67 expression levels in substantial renal cell carcinoma

    To investigate the effectiveness of an automatic analysis framework based on 3D-CT multi-scale features in predicting Ki67 expression levels in substantial renal cell carcinoma (RCC).

    Huancheng Yang, Jiashan Lin, Hanlin Liu, Jiehua Yao, Qianyu Lin in Insights into Imaging (2023)

  11. Article

    Open Access

    Acute traumatic coma awakening by right median nerve electrical stimulation: a randomised controlled trial

    Severe traumatic brain injury (TBI) leads to acute coma and may result in prolonged disorder of consciousness (pDOC). We aimed to determine whether right median nerve electrical stimulation is a safe and effec...

    **ang Wu, Li **e, ** Lei, Jiemin Yao, Jiarong Li, Lixin Ruan in Intensive Care Medicine (2023)

  12. Article

    Open Access

    Two vs three cycles of neoadjuvant sintilimab plus chemotherapy for resectable non-small-cell lung cancer: neoSCORE trial

    Miner Shao, Jie Yao, Yunke Wang, Lufeng Zhao in Signal Transduction and Targeted Therapy (2023)

  13. Article

    Open Access

    Exhaustive drainage versus fixed-time drainage for chronic subdural hematoma after one-burr hole craniostomy (ECHO): study protocol for a multicenter randomized controlled trial

    Chronic subdural hematomas (CSDHs) are one of the most common neurosurgical conditions. The standard surgical technique includes burr-hole craniostomy, followed by intraoperative irrigation and placement of su...

    Liang Wu, Yunwei Ou, Bingcheng Zhu, Xufei Guo, **aofan Yu, Long Xu, **** Li in Trials (2023)

  14. Article

    Open Access

    Consolidation radiographic morphology can be an indicator of the pathological basis and prognosis of partially solid nodules

    Part-solid nodules (PSNs) have gradually shifted to defining special clinical subtypes. Commonly, the solid portions of PSNs show various radiological morphologies, of which the corresponding pathological basi...

    Mei **e, Jie Gao, **dong Ma, Chongchong Wu, Xuelei Zang in BMC Pulmonary Medicine (2022)

  15. Article

    Open Access

    Study of female pelvic floor muscle in overactive bladder based on MRI 3D reconstruction

    This study examined the three-dimensional (3D) morphological changes of the urination and urinary continence anatomical structures in overactive bladder (OAB) patients, to offer a morphological data for OAB di...

    Yangyun Wang, Jie Yao, Na Chen, **g**g Liu, Guowei Shi, Yi Wu in BMC Urology (2022)

  16. Article

    CircTMC5 promotes gastric cancer progression and metastasis by targeting miR-361-3p/RABL6

    Gastric cancer (GC) is common in East Asia, yet its molecular and pathogenic mechanisms remain unclear. Circular RNAs (circRNAs) are differentially expressed in GC and may be promising biomarkers. Here, we inv...

    Peng Xu, **aoLan Xu, **ao Wu, Li**ang Zhang, Lei Meng, ZhangMing Chen in Gastric Cancer (2022)

  17. No Access

    Article

    Osteopontin improves sensitivity to tyrosine kinase inhibitor in lung adenocarcinoma in vitro by promoting epidermal growth factor receptor phosphorylation

    Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR) improve the prognosis of lung adenocarcinoma (LUAD). However, the factors affecting its clinical efficacy remain unclear. Thi...

    Yu-** Wang, Qing-Wen Wang, Dong-Hu Yu in Journal of Cancer Research and Clinical On… (2021)

  18. No Access

    Article

    Multi-ancestry genome-wide gene–sleep interactions identify novel loci for blood pressure

    Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the ...

    Heming Wang, Raymond Noordam, Brian E. Cade, Karen Schwander in Molecular Psychiatry (2021)

  19. Article

    Open Access

    Suppression of 4.1R enhances the potency of NKG2D-CAR T cells against pancreatic carcinoma via activating ERK signaling pathway

    Pancreatic carcinoma (PC) is one of the most common malignancies. Chimeric antigen receptor (CAR)-modified T cells has achieved remarkable efficacy in the treatment of hematological malignancies. However, lack...

    Yaoxin Gao, Haizhen Lin, Dandan Guo, Sijia Cheng, Ying Zhou, Li Zhang in Oncogenesis (2021)

  20. No Access

    Article

    SNHG10 Promotes Cell Proliferation and Migration in Gastric Cancer by Targeting miR-495-3p/CTNNB1 Axis

    Long non-coding RNAs have been acknowledged as the crucial regulators in the progression of human cancers, including gastric cancer (GC). Small nucleolar RNA host gene 10 (SNHG10) has been identified as an onc...

    **u Yuan, Tianwen Yang, Yun Xu, Shan Ou, Peng Shi in Digestive Diseases and Sciences (2021)

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