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Article
Open AccessAnalysis of tumor abnormal protein expression and epidermal growth factor receptor mutation status in non-small cell lung cancer
The level of tumor abnormal protein (TAP) level has a significant impact on tumor growth, recurrence, and metastasis. Previous studies have highlighted the influence of the mutations in exons 19 and 21 of the ...
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Article
Research on the Influence of Mechanical Characteristics of a Ferrofluid Inertial Damper on the Vibration-Dam** Performance
The low-frequency vibration is one of the main issues in develo** loading Aerospace. Using ferrofluid inertial dampers (FIDs) is an effective method to inhibit these low-frequency vibrations. However, the me...
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Article
Machine learning–driven SERS analysis platform for rapid and accurate detection of precancerous lesions of gastric cancer
A novel approach is proposed leveraging surface-enhanced Raman spectroscopy (SERS) combined with machine learning (ML) techniques, principal component analysis (PCA)-centroid displacement–based nearest neighbo...
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Article
Radiosensitization effect of quinoline-indole-schiff base derivative 10E on non-small cell lung cancer cells in vitro and in tumor xenografts
Radioresistance is an inevitable obstacle in the clinical treatment of inoperable patients with non-small cell lung cancer (NSCLC). Combining treatment with radiosensitizers may improve the efficacy of radioth...
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Article
Open AccessNovel artificial intelligence algorithms for diabetic retinopathy and diabetic macular edema
Diabetic retinopathy (DR) and diabetic macular edema (DME) are major causes of visual impairment that challenge global vision health. New strategies are needed to tackle these growing global health problems, a...
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Article
Open AccessProgress of single-cell RNA sequencing combined with spatial transcriptomics in tumour microenvironment and treatment of pancreatic cancer
In recent years, single-cell analyses have revealed the heterogeneity of the tumour microenvironment (TME) at the genomic, transcriptomic, and proteomic levels, further improving our understanding of the mecha...
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Article
Correction: XAF1 overexpression inhibits the malignant progression and cisplatin resistance of NSCLC by activating endoplasmic reticulum stress
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Article
Open AccessEnhancement of phase transition temperature through hydrogen bond modification in molecular ferroelectrics
Molecular ferroelectrics are attracting great interest due to their light weight, mechanical flexibility, low cost, ease of processing and environmental friendliness. These advantages make molecular ferroelect...
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Article
Open AccessA “twelve-section ultrasonic screening and diagnosis method” and management system for screening and treating neonatal congenital heart disease at the grassroots level in Tang County, Hebei Province, China
To explore a method for screening and diagnosing neonatal congenital heart disease (CHD) applicable to grassroots level, evaluate the prevalence of CHD, and establish a hierarchical management system for CHD s...
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Article
An investigation on the mechanical properties of a multi-layer film coated PMMA by nanoindentation
This study investigates the mechanical properties of a novel multi-layer Silane/Indium Tin Oxide (ITO) film based on Polymethyl methacrylate (PMMA). Nanoindentation tests, theoretical analysis, and numerical simu...
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Article
Open AccessSpin disorder control of topological spin texture
Stabilization of topological spin textures in layered magnets has the potential to drive the development of advanced low-dimensional spintronics devices. However, achieving reliable and flexible manipulation o...
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Article
Dipolar spin wave packet transport in a van der Waals antiferromagnet
Antiferromagnets are promising platforms for transduction and transmission of quantum information via magnons—the quanta of spin waves—and they offer advantages over ferromagnets in regard to dissipation, spee...
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Article
Open AccessWhy does advertising work? exploring the neural mechanism of concreteness and emotional effects of donation advertising slogans
Advertising is methods to encourage donations, and text is one of the most crucial fundamental elements in advertising. Therefore, we chose advertising slogans as the focus of this study. The main goal of this...
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Article
MicroRNA-29b-3p reduces cisplatin resistance in non-small cell lung cancer by targeting myeloid cell leukemia-1
Non-small cell lung cancer (NSCLC) is a heterogeneous series of tumors. Given the implication of microRNA-29b-3p (miR-29b-3p) in cisplatin resistance in NSCLC, this study expounded on the further mechanism.
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Open AccessXELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...
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Article
Open AccessThe radiological characteristics, tertiary lymphoid structures, and survival status associated with EGFR mutation in patients with subsolid nodules like stage I-II LUAD.
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) recommended for the patients with subsolid nodule in early lung cancer stage is not routinely. The clinical value and impact in patients ...
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Article
XAF1 overexpression inhibits the malignant progression and cisplatin resistance of NSCLC by activating endoplasmic reticulum stress
XIAP-associated factor 1 (XAF1) has been found to participate in the progression of multiple human cancers. Nevertheless, its role as well as the reaction mechanism in non-small cell lung cancer (NSCLC) still ...
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Article
Retraction Note: MEK/ERK pathway activation by insulin receptor isoform alteration is associated with the abnormal proliferation and differentiation of intestinal epithelial cells in diabetic mice
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Article
Open AccessGenetic drivers of heterogeneity in type 2 diabetes pathophysiology
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic c...
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Article
Design and optimization of mobile learning applications based on Hierarchical Bayes conjoint models of user preferences
When develo** new mobile applications, it is critical to accurately understand the needs of the target users at the early stage, so that the designed products can better match user preferences and improve us...
