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Article
Open AccessA Randomized, Open-Label, Phase I, Single-Dose Study of Antisense Oligonucleotide, Vupanorsen, in Chinese Adults with Elevated Triglycerides
Vupanorsen is a GalNAc3-conjugated antisense oligonucleotide targeting angiopoietin-like 3 (ANGPTL3) mRNA shown to reduce atherogenic lipoproteins in individuals with dyslipidemia.
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Article
Group classification for one type of space-time fractional quasilinear parabolic equation
In this paper, we present the Lie symmetry analysis for the space-time fractional quasilinear parabolic equation. A group classification is then carried out by investigating the coefficient functions p(t, x, u),
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Article
Open AccessLie Symmetry Analysis, Power Series Solutions and Conservation Laws of (2+1)-Dimensional Time Fractional Modified Bogoyavlenskii–Schiff Equations
In this paper, Lie symmetry analysis method is applied to the (2+1)-dimensional time fractional modified Bogoyavlenskii–Schiff equations, which is an important model in physics. The one-dimensional optimal sys...
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Article
Microneedle biomedical devices
Microneedle (MN) technologies have gained interest for biomedical applications, ranging from drug delivery to sensing and tissue sampling in skin and internal organs. The microscale feature of MN systems allow...
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Article
Advances of nanoparticles in transmucosal drug delivery
Transmucosal drug administration represents a potential strategy for enhancing treatment efficacy and reducing side effects by avoiding the first-pass effect into the systemic circulation and delivering therap...
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Article
Stretchable graphene–hydrogel interfaces for wearable and implantable bioelectronics
Soft, stretchable and biocompatible conductors are required for on-skin and implantable electronics. Laser-induced graphene (LIG) can offer tuneable physical and chemical properties, and is of particular value...
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Article
Open AccessAn in situ dual-anchoring strategy for enhanced immobilization of PD-L1 to treat autoimmune diseases
Immune checkpoints play key roles in maintaining self-tolerance. Targeted potentiation of the checkpoint molecule PD-L1 through in situ manipulation offers clinical promise for patients with autoimmune disease...
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Article
Exploration of tunable, low-depletion novel resistor paste system based on molybdenum-based functional phase modulation
Highly reliable resistor pastes are essential for the development of the electronics industry. However, in recent years, the prices of precious metals used in resistor pastes have continued to rise. Therefore,...
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Article
Open AccessPre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer
Phototherapy of deep tumors still suffers from many obstacles, such as limited near-infrared (NIR) tissue penetration depth and low accumulation efficiency within the target sites. Herein, stimuli-sensitive tu...
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Article
Open AccessScarless wound healing programmed by core-shell microneedles
Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing...
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Article
Open AccessSafety, Tolerability and Pharmacokinetics of Single and Multiple Doses of Mirogabalin in Healthy Chinese Participants: A Randomized, Double-Blind, Placebo-Controlled Study
Mirogabalin is a treatment option for patients with neuropathic pain; however, safety, tolerability, and pharmacokinetics (PK) data specifically for Chinese individuals are limited to a single-dose study. We a...
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Article
Open AccessOptimal design of dual air-gap closed-loop TMR current sensor based on minimum magnetic field uniformity coefficient
Advanced sensor technology provides accurate information for transparent monitoring and real-time control of the power grid. Tunnel magnetoresistance (TMR) elements with high sensitivity and linearity provide ...
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Article
Pharmacokinetics of benapenem for injection in subjects with mild to moderate renal impairment
This study evaluated the pharmacokinetic (PK) characteristics of benapenem in subjects with mild to moderate renal impairment to provide a reference for benapenem dosing regimens in this patient population.
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Article
Microneedle-mediated therapy for cardiovascular diseases
Cardiovascular diseases remain a leading cause of global disease burden. To date, the limited drug delivery efficacy confines the therapeutic effect in most conventional approaches, such as intramyocardial inj...
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Article
Treating diabetes with ‘cookies’
Genetic code expansion is emerging as a promising strategy to precisely regulate protein expression. A new study engineered cells that enabled noncanonical-amino-acid-triggered insulin expression to rapidly re...
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Article
Open AccessPharmacokinetics of Levornidazole Tablet in Healthy Chinese Subjects and Proposed Dosing Regimen Based on Pharmacokinetic/Pharmacodynamic Analysis
Levornidazole is a novel nitroimidazole antimicrobial agent active against anaerobes. We aimed to investigate the pharmacokinetic (PK) profile of levornidazole after single and multiple oral doses of levornida...
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Article
Safety, Tolerability and Pharmacokinetics of Single Ascending and Multiple Oral Doses of Tegoprazan in Healthy Chinese Subjects
Tegoprazan is one of the potassium-competitive acid blockers (P-CABs). It exhibits its anti-secretory effects by competitively and reversibly blocking the availability of K+ of the H+, K+-ATPase. This study was d...
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Article
Streptomyces sp. S501, a Marine Petroleum-Degrading Actinobacterium Isolated from Sediment of Yalujiang Estuary, Northern China, and Its Genome Annotation
Streptomyces sp. S501, which was isolated from the sediment of Yalujiang Estuary in China, was the first marine Streptomyces species discovered to act as an excellent petroleum degrader. We analyzed the effect of...
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Article
Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs
Glucose-responsive insulin delivery systems that mimic pancreatic endocrine function could enhance health and improve quality of life for people with type 1 and type 2 diabetes with reduced β-cell function. Ho...
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Article
Glucose-responsive oral insulin delivery for postprandial glycemic regulation
Controlling postprandial glucose levels for diabetic patients is critical to achieve the tight glycemic control that decreases the risk for develo** long-term micro- and macrovascular complications. Herein, ...
