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Article
Open AccessFTO promotes clear cell renal cell carcinoma progression via upregulation of PDK1 through an m6A dependent pathway
FTO, as an m6A mRNA demethylase, is involved in various cancers. However, the role of FTO in clear cell renal cell carcinoma (ccRCC) remains unclear. In the present study, we discovered FTO is upregulated in ccRC...
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Article
Open AccessSMAD3 and FTO are involved in miR-5581-3p-mediated inhibition of cell migration and proliferation in bladder cancer
Previous research evidence suggests that microRNAs (miRNAs) play an indispensable role in onset and progression of bladder cancer (BCa). Here, we explored the functions and mechanisms of miR-5581-3p in BCa. mi...
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Article
Open AccesscircKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis
Circular RNAs (circRNAs) play essential roles in human bladder cancer (BCa) development, however, unusual expression patterns and functional dysfunction of circRNAs in BCa have not been evaluated. In this stud...
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Article
Open AccessUpregulation of ARNTL2 is associated with poor survival and immune infiltration in clear cell renal cell carcinoma
Aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2) is a member of the PAS superfamily. Previous studies explored the carcinogenic roles of transcription factor ARNTL2 in human malignancies. However...
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Article
TaCKX gene family, at large, is associated with thousand-grain weight and plant height in common wheat
We used SMRT sequencing and explored the haplotypes of TaCKX genes, linked with thousand-grain weight and plant height, and developed the functionally validated markers, which can be used in the marker-assisted b...
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Article
Low molecular weight glutenin subunit gene composition at Glu-D3 loci of Aegilops tauschii and common wheat and a further view of wheat evolution
A comprehensive comparison of LMW-GS genes between Ae. tauschii and its progeny common wheat.
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Article
Open AccessDiversity, distribution of Puroindoline genes and their effect on kernel hardness in a diverse panel of Chinese wheat germplasm
Kernel hardness, which has great influence on the end-use properties of common wheat, is mainly controlled by Puroindoline genes, Pina and Pinb. Using EcoTILLING platform, we herein investigated the allelic varia...
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Article
Open AccessGenetic diversity, population structure and marker-trait associations for agronomic and grain traits in wild diploid wheat Triticum urartu
Wild diploid wheat, Triticum urartu (T. urartu) is the progenitor of bread wheat, and understanding its genetic diversity and genome function will provide considerable reference for dissecting genomic information...
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Article
Development of an integrated linkage map of einkorn wheat and its application for QTL map** and genome sequence anchoring
An integrated genetic map was constructed for einkorn wheat A genome and provided valuable information for QTL map** and genome sequence anchoring.
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Article
Open AccessComposition, variation, expression and evolution of low-molecular-weight glutenin subunit genes in Triticum urartu
Wheat (AABBDD, 2n = 6x = 42) is a major dietary component for many populations across the world. Bread-making quality of wheat is mainly determined by glutenin subunits, but it remains challenging to elucidate...
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Article
Isolation of a gibberellin-insensitive dwarfing gene, Rht-B1e, and development of an allele-specific PCR marker
Gibberellins (GAs) are important phytohormones in plants. GAs promote plant growth by inducing the degradation of DELLA proteins, which serve as GA signal repressors. The semi-dwarfing genes Rht-B1b and Rht-D1b, ...
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Article
The genes for gibberellin biosynthesis in wheat
The gibberellin biosynthesis pathway is well defined in Arabidopsis and features seven key enzymes including ent-copalyl diphosphate synthase (CPS), ent-kaurene synthase (KS), ent-kaurene oxidase (KO), ent-kauren...
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Article
PCR-based isolation and identification of full-length low-molecular-weight glutenin subunit genes in bread wheat (Triticum aestivum L.)
Low-molecular-weight glutenin subunits (LMW-GSs) are encoded by a multi-gene family and are essential for determining the quality of wheat flour products, such as bread and noodles. However, the exact role or ...
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Article
Open AccessInvestigation of genetic diversity and population structure of common wheat cultivars in northern China using DArT markers
In order to help establish heterotic groups of Chinese northern wheat cultivars (lines), Diversity arrays technology (DArT) markers were used to investigate the genetic diversity and population structure of Ch...
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Article
Open AccessDevelopment of a new marker system for identifying the complex members of the low-molecular-weight glutenin subunit gene family in bread wheat (Triticum aestivum L.)
Low-molecular-weight glutenin subunits (LMW-GSs) play an important role in determining the bread-making quality of bread wheat. However, LMW-GSs display high polymorphic protein complexes encoded by multiple g...
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Article
Identification of new T1BL.1RS translocation lines derived from wheat (Triticum aestivum L. cultivar “**aoyan No. 6”) and rye hybridization
Two new T1BL.1RS translocation lines, 48112 and 89121, derived from cross between common wheat (Triticum aestivum L.) cultivar “**aoyan No. 6” and rye (Secale cereale L.) cultivar “German White”, were developed a...
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Article
Allelic variation, sequence determination and microsatellite screening at the XGWM261 locus in Chinese hexaploid wheat (Triticum aestivum) varieties
Wheat microsatellite XGWM261, due to its closely linked to the dwarfing gene Rht8, has been adopted as the diagnostic molecular marker of Rht8. Screening 408 Chinese and 98 exotic varieties showed 13 allele varia...
